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AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation

The human AAA+ ATPase p97, also known as valosin-containing protein, a potential target for cancer therapeutics, plays a vital role in the clearing of misfolded proteins. p97 dysfunction is also known to play a crucial role in several neurodegenerative disorders, such as MultiSystem Proteinopathy 1...

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Detalles Bibliográficos
Autores principales:	Caffrey, Brian, Zhu, Xing, Berezuk, Alison, Tuttle, Katharine, Chittori, Sagar, Subramaniam, Sriram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517850/ https://www.ncbi.nlm.nih.gov/pubmed/34520757 http://dx.doi.org/10.1016/j.jbc.2021.101187

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