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Metformin exerts a synergistic effect with venetoclax by downregulating Mcl-1 protein in acute myeloid leukemia
Background: Recently, one of the specific BH3-mimetics, Venetoclax has been approved by FDA providing new options for newly diagnosed AML patient especially who are unfitted to receive conventional chemotherapy. Though the clinical success of venetoclax has been achieved in clinical outcomes such as...
Autores principales: | Zhou, Fang-jiao, Zeng, Chen-xing, Kuang, Wei, Cheng, Cong, Liu, Hong-cai, Yan, Xue-ying, Chen, Xiao-ping, Zhou, Gan, Cao, Shan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518002/ https://www.ncbi.nlm.nih.gov/pubmed/34659562 http://dx.doi.org/10.7150/jca.60208 |
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