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PET/CT‐Detected myofibroblastoma of the breast with bizarre cells: A potential diagnostic pitfall of malignancy
Myofibroblastoma (MFB) is a rare benign mesenchymal tumor usually occurring in the breast parenchyma. This tumor can present as a palpable nodule or can be incidentally detected as a nonpalpable mass on routine screening mammogram. We first report a rare case of histologically proven MFB of the brea...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518039/ https://www.ncbi.nlm.nih.gov/pubmed/34196064 http://dx.doi.org/10.1111/tbj.14269 |
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author | Angelico, Giuseppe Broggi, Giuseppe Spadola, Saveria Mulè, Antonino Magro, Gaetano |
author_facet | Angelico, Giuseppe Broggi, Giuseppe Spadola, Saveria Mulè, Antonino Magro, Gaetano |
author_sort | Angelico, Giuseppe |
collection | PubMed |
description | Myofibroblastoma (MFB) is a rare benign mesenchymal tumor usually occurring in the breast parenchyma. This tumor can present as a palpable nodule or can be incidentally detected as a nonpalpable mass on routine screening mammogram. We first report a rare case of histologically proven MFB of the breast revealed by fluoro‐deoxyglucose uptake on PET‐CT examination in a patient with a lung nodule. Tumor exhibited an unusual morphology, being predominantly composed of polygonal, epithelioid, and deciduoid‐like cells set in a myxoid stroma. The most striking feature was the multifocal presence of atypical/bizarre, mono/bi‐nucleated cells that, in addition to diffuse myxoid stromal changes, were a concern of malignancy, especially on core biopsy. The final diagnosis of MFB was achieved on surgically resected specimen and, similarly to other benign soft tissue tumors (especially leiomyoma and schwannoma/neurofibroma), the term “bizarre cell MFB of the breast” is proposed to emphasize the degenerative/reactive nature of the atypia. |
format | Online Article Text |
id | pubmed-8518039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85180392021-10-21 PET/CT‐Detected myofibroblastoma of the breast with bizarre cells: A potential diagnostic pitfall of malignancy Angelico, Giuseppe Broggi, Giuseppe Spadola, Saveria Mulè, Antonino Magro, Gaetano Breast J Case Reports Myofibroblastoma (MFB) is a rare benign mesenchymal tumor usually occurring in the breast parenchyma. This tumor can present as a palpable nodule or can be incidentally detected as a nonpalpable mass on routine screening mammogram. We first report a rare case of histologically proven MFB of the breast revealed by fluoro‐deoxyglucose uptake on PET‐CT examination in a patient with a lung nodule. Tumor exhibited an unusual morphology, being predominantly composed of polygonal, epithelioid, and deciduoid‐like cells set in a myxoid stroma. The most striking feature was the multifocal presence of atypical/bizarre, mono/bi‐nucleated cells that, in addition to diffuse myxoid stromal changes, were a concern of malignancy, especially on core biopsy. The final diagnosis of MFB was achieved on surgically resected specimen and, similarly to other benign soft tissue tumors (especially leiomyoma and schwannoma/neurofibroma), the term “bizarre cell MFB of the breast” is proposed to emphasize the degenerative/reactive nature of the atypia. John Wiley and Sons Inc. 2021-06-30 2021-09 /pmc/articles/PMC8518039/ /pubmed/34196064 http://dx.doi.org/10.1111/tbj.14269 Text en © 2021 The Authors. The Breast Journal published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Reports Angelico, Giuseppe Broggi, Giuseppe Spadola, Saveria Mulè, Antonino Magro, Gaetano PET/CT‐Detected myofibroblastoma of the breast with bizarre cells: A potential diagnostic pitfall of malignancy |
title | PET/CT‐Detected myofibroblastoma of the breast with bizarre cells: A potential diagnostic pitfall of malignancy |
title_full | PET/CT‐Detected myofibroblastoma of the breast with bizarre cells: A potential diagnostic pitfall of malignancy |
title_fullStr | PET/CT‐Detected myofibroblastoma of the breast with bizarre cells: A potential diagnostic pitfall of malignancy |
title_full_unstemmed | PET/CT‐Detected myofibroblastoma of the breast with bizarre cells: A potential diagnostic pitfall of malignancy |
title_short | PET/CT‐Detected myofibroblastoma of the breast with bizarre cells: A potential diagnostic pitfall of malignancy |
title_sort | pet/ct‐detected myofibroblastoma of the breast with bizarre cells: a potential diagnostic pitfall of malignancy |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518039/ https://www.ncbi.nlm.nih.gov/pubmed/34196064 http://dx.doi.org/10.1111/tbj.14269 |
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