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Kras(G12D) induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells

BACKGROUND: Pancreatic ductal adenocarcinoma initiation is most frequently caused by Kras mutations. RESULTS: Here, we apply biological, biochemical, and network biology methods to validate GEMM-derived cell models using inducible Kras(G12D) expression. We describe the time-dependent, chromatin remo...

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Detalles Bibliográficos
Autores principales:	Mathison, Angela J., Kerketta, Romica, de Assuncao, Thiago Milech, Leverence, Elise, Zeighami, Atefeh, Urrutia, Guillermo, Stodola, Timothy J., di Magliano, Marina Pasca, Iovanna, Juan L., Zimmermann, Michael T., Lomberk, Gwen, Urrutia, Raul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518179/ https://www.ncbi.nlm.nih.gov/pubmed/34649604 http://dx.doi.org/10.1186/s13059-021-02498-6

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