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Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers

BACKGROUND: PTEN is a multi-functional tumor suppressor protein regulating cell growth, immune signaling, neuronal function, and genome stability. Experimental characterization can help guide the clinical interpretation of the thousands of germline or somatic PTEN variants observed in patients. Two...

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Detalles Bibliográficos
Autores principales:	Matreyek, Kenneth A., Stephany, Jason J., Ahler, Ethan, Fowler, Douglas M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518224/ https://www.ncbi.nlm.nih.gov/pubmed/34649609 http://dx.doi.org/10.1186/s13073-021-00984-x

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