Mechanistic Aspects of the Palladium‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reaction

The story of C−C bond formation includes several reactions, and surely Suzuki‐Miyaura is among the most outstanding ones. Herein, a brief historical overview of insights regarding the reaction mechanism is provided. In particular, the formation of the catalytically active species is probably the mai...

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Autores principales: D'Alterio, Massimo C., Casals‐Cruañas, Èric, Tzouras, Nikolaos V., Talarico, Giovanni, Nolan, Steven P., Poater, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518397/
https://www.ncbi.nlm.nih.gov/pubmed/34269488
http://dx.doi.org/10.1002/chem.202101880
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author D'Alterio, Massimo C.
Casals‐Cruañas, Èric
Tzouras, Nikolaos V.
Talarico, Giovanni
Nolan, Steven P.
Poater, Albert
author_facet D'Alterio, Massimo C.
Casals‐Cruañas, Èric
Tzouras, Nikolaos V.
Talarico, Giovanni
Nolan, Steven P.
Poater, Albert
author_sort D'Alterio, Massimo C.
collection PubMed
description The story of C−C bond formation includes several reactions, and surely Suzuki‐Miyaura is among the most outstanding ones. Herein, a brief historical overview of insights regarding the reaction mechanism is provided. In particular, the formation of the catalytically active species is probably the main concern, thus the preactivation is in competition with, or even assumes the role of the rate determining step (rds) of the overall reaction. Computational chemistry is key in identifying the rds and thus leading to milder conditions on an experimental level by means of predictive catalysis.
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spelling pubmed-85183972021-10-21 Mechanistic Aspects of the Palladium‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reaction D'Alterio, Massimo C. Casals‐Cruañas, Èric Tzouras, Nikolaos V. Talarico, Giovanni Nolan, Steven P. Poater, Albert Chemistry Reviews The story of C−C bond formation includes several reactions, and surely Suzuki‐Miyaura is among the most outstanding ones. Herein, a brief historical overview of insights regarding the reaction mechanism is provided. In particular, the formation of the catalytically active species is probably the main concern, thus the preactivation is in competition with, or even assumes the role of the rate determining step (rds) of the overall reaction. Computational chemistry is key in identifying the rds and thus leading to milder conditions on an experimental level by means of predictive catalysis. John Wiley and Sons Inc. 2021-08-09 2021-09-24 /pmc/articles/PMC8518397/ /pubmed/34269488 http://dx.doi.org/10.1002/chem.202101880 Text en © 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
D'Alterio, Massimo C.
Casals‐Cruañas, Èric
Tzouras, Nikolaos V.
Talarico, Giovanni
Nolan, Steven P.
Poater, Albert
Mechanistic Aspects of the Palladium‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reaction
title Mechanistic Aspects of the Palladium‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reaction
title_full Mechanistic Aspects of the Palladium‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reaction
title_fullStr Mechanistic Aspects of the Palladium‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reaction
title_full_unstemmed Mechanistic Aspects of the Palladium‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reaction
title_short Mechanistic Aspects of the Palladium‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reaction
title_sort mechanistic aspects of the palladium‐catalyzed suzuki‐miyaura cross‐coupling reaction
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518397/
https://www.ncbi.nlm.nih.gov/pubmed/34269488
http://dx.doi.org/10.1002/chem.202101880
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