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Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes
Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory to oral drugs as with dermatophytoma. We evaluated the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes. Of the 223 subjects who were enrolled in a previous st...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518491/ https://www.ncbi.nlm.nih.gov/pubmed/34212423 http://dx.doi.org/10.1111/1346-8138.16035 |
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| author | Watanabe, Shinichi Iozumi, Ken Abe, Masatoshi Ito, Yoshiko Uesugi, Takashi Onoduka, Takashi Kato, Ichiro Kato, Fumihiro Kodama, Kazuo Takahashi, Hidetoshi Takeda, Osamu Tomizawa, Koki Tateishi, Yasuki Fujii, Mizue Mayama, Jun Muramoto, Fumio Yasuda, Hidemi Yamanaka, Kiyomitsu Oh‐i, Tsunao Kasai, Hiroko Tsuboi, Ryoji Hattori, Naoko Maruyama, Ryuji Omi, Tokuya Shimoyama, Harunari Nakasu, Ichiro Watanabe‐Okada, Emiko Nishimoto, Shuhei Mochizuki, Takashi Fukuzawa, Masao Seishima, Mariko Sugiura, Kazumitsu Yamamoto, Osamu Shindo, Masahisa Kiryu, Hiroe Kusuhara, Masahiro Takenaka, Motoi |
| author_facet | Watanabe, Shinichi Iozumi, Ken Abe, Masatoshi Ito, Yoshiko Uesugi, Takashi Onoduka, Takashi Kato, Ichiro Kato, Fumihiro Kodama, Kazuo Takahashi, Hidetoshi Takeda, Osamu Tomizawa, Koki Tateishi, Yasuki Fujii, Mizue Mayama, Jun Muramoto, Fumio Yasuda, Hidemi Yamanaka, Kiyomitsu Oh‐i, Tsunao Kasai, Hiroko Tsuboi, Ryoji Hattori, Naoko Maruyama, Ryuji Omi, Tokuya Shimoyama, Harunari Nakasu, Ichiro Watanabe‐Okada, Emiko Nishimoto, Shuhei Mochizuki, Takashi Fukuzawa, Masao Seishima, Mariko Sugiura, Kazumitsu Yamamoto, Osamu Shindo, Masahisa Kiryu, Hiroe Kusuhara, Masahiro Takenaka, Motoi |
| author_sort | Watanabe, Shinichi |
| collection | PubMed |
| description | Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory to oral drugs as with dermatophytoma. We evaluated the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes. Of the 223 subjects who were enrolled in a previous study, a post‐hoc analysis of 82 subjects with longitudinal spikes was performed in this study. The opacity ratio of longitudinal spikes was decreased over time from 8.1 to 0.9 at the final assessment. In addition, the longitudinal spike disappearance rate increased early after the application to 81.7% at the final assessment. Therefore, 10% efinaconazole solution can be a first‐line drug for longitudinal spikes, which have been regarded as refractory to oral drugs. |
| format | Online Article Text |
| id | pubmed-8518491 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-85184912021-10-21 Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes Watanabe, Shinichi Iozumi, Ken Abe, Masatoshi Ito, Yoshiko Uesugi, Takashi Onoduka, Takashi Kato, Ichiro Kato, Fumihiro Kodama, Kazuo Takahashi, Hidetoshi Takeda, Osamu Tomizawa, Koki Tateishi, Yasuki Fujii, Mizue Mayama, Jun Muramoto, Fumio Yasuda, Hidemi Yamanaka, Kiyomitsu Oh‐i, Tsunao Kasai, Hiroko Tsuboi, Ryoji Hattori, Naoko Maruyama, Ryuji Omi, Tokuya Shimoyama, Harunari Nakasu, Ichiro Watanabe‐Okada, Emiko Nishimoto, Shuhei Mochizuki, Takashi Fukuzawa, Masao Seishima, Mariko Sugiura, Kazumitsu Yamamoto, Osamu Shindo, Masahisa Kiryu, Hiroe Kusuhara, Masahiro Takenaka, Motoi J Dermatol Original Articles Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory to oral drugs as with dermatophytoma. We evaluated the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes. Of the 223 subjects who were enrolled in a previous study, a post‐hoc analysis of 82 subjects with longitudinal spikes was performed in this study. The opacity ratio of longitudinal spikes was decreased over time from 8.1 to 0.9 at the final assessment. In addition, the longitudinal spike disappearance rate increased early after the application to 81.7% at the final assessment. Therefore, 10% efinaconazole solution can be a first‐line drug for longitudinal spikes, which have been regarded as refractory to oral drugs. John Wiley and Sons Inc. 2021-07-01 2021-10 /pmc/articles/PMC8518491/ /pubmed/34212423 http://dx.doi.org/10.1111/1346-8138.16035 Text en © 2021 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Original Articles Watanabe, Shinichi Iozumi, Ken Abe, Masatoshi Ito, Yoshiko Uesugi, Takashi Onoduka, Takashi Kato, Ichiro Kato, Fumihiro Kodama, Kazuo Takahashi, Hidetoshi Takeda, Osamu Tomizawa, Koki Tateishi, Yasuki Fujii, Mizue Mayama, Jun Muramoto, Fumio Yasuda, Hidemi Yamanaka, Kiyomitsu Oh‐i, Tsunao Kasai, Hiroko Tsuboi, Ryoji Hattori, Naoko Maruyama, Ryuji Omi, Tokuya Shimoyama, Harunari Nakasu, Ichiro Watanabe‐Okada, Emiko Nishimoto, Shuhei Mochizuki, Takashi Fukuzawa, Masao Seishima, Mariko Sugiura, Kazumitsu Yamamoto, Osamu Shindo, Masahisa Kiryu, Hiroe Kusuhara, Masahiro Takenaka, Motoi Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes |
| title | Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes |
| title_full | Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes |
| title_fullStr | Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes |
| title_full_unstemmed | Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes |
| title_short | Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes |
| title_sort | clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes |
| topic | Original Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518491/ https://www.ncbi.nlm.nih.gov/pubmed/34212423 http://dx.doi.org/10.1111/1346-8138.16035 |
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