Controlling Coagulation in Blood with Red Light

Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin‐binding aptamer with a red‐light photocleavable linker derived from Cy7 by Cu‐catalyzed Click chemistry. We were able to show that we can succ...

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Detalles Bibliográficos
Autores principales: Müller, Patricia, Sahlbach, Marlen, Gasper, Simone, Mayer, Günter, Müller, Jens, Pötzsch, Bernd, Heckel, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518524/
https://www.ncbi.nlm.nih.gov/pubmed/34293228
http://dx.doi.org/10.1002/anie.202108468
Descripción
Sumario:Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin‐binding aptamer with a red‐light photocleavable linker derived from Cy7 by Cu‐catalyzed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood—restoring the blood's natural coagulation capability.

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