Controlling Coagulation in Blood with Red Light

Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin‐binding aptamer with a red‐light photocleavable linker derived from Cy7 by Cu‐catalyzed Click chemistry. We were able to show that we can succ...

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Detalles Bibliográficos
Autores principales: Müller, Patricia, Sahlbach, Marlen, Gasper, Simone, Mayer, Günter, Müller, Jens, Pötzsch, Bernd, Heckel, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518524/
https://www.ncbi.nlm.nih.gov/pubmed/34293228
http://dx.doi.org/10.1002/anie.202108468
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author Müller, Patricia
Sahlbach, Marlen
Gasper, Simone
Mayer, Günter
Müller, Jens
Pötzsch, Bernd
Heckel, Alexander
author_facet Müller, Patricia
Sahlbach, Marlen
Gasper, Simone
Mayer, Günter
Müller, Jens
Pötzsch, Bernd
Heckel, Alexander
author_sort Müller, Patricia
collection PubMed
description Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin‐binding aptamer with a red‐light photocleavable linker derived from Cy7 by Cu‐catalyzed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood—restoring the blood's natural coagulation capability.
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spelling pubmed-85185242021-10-21 Controlling Coagulation in Blood with Red Light Müller, Patricia Sahlbach, Marlen Gasper, Simone Mayer, Günter Müller, Jens Pötzsch, Bernd Heckel, Alexander Angew Chem Int Ed Engl Research Articles Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin‐binding aptamer with a red‐light photocleavable linker derived from Cy7 by Cu‐catalyzed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood—restoring the blood's natural coagulation capability. John Wiley and Sons Inc. 2021-08-31 2021-10-04 /pmc/articles/PMC8518524/ /pubmed/34293228 http://dx.doi.org/10.1002/anie.202108468 Text en © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Müller, Patricia
Sahlbach, Marlen
Gasper, Simone
Mayer, Günter
Müller, Jens
Pötzsch, Bernd
Heckel, Alexander
Controlling Coagulation in Blood with Red Light
title Controlling Coagulation in Blood with Red Light
title_full Controlling Coagulation in Blood with Red Light
title_fullStr Controlling Coagulation in Blood with Red Light
title_full_unstemmed Controlling Coagulation in Blood with Red Light
title_short Controlling Coagulation in Blood with Red Light
title_sort controlling coagulation in blood with red light
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518524/
https://www.ncbi.nlm.nih.gov/pubmed/34293228
http://dx.doi.org/10.1002/anie.202108468
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