Loss of PIKfyve drives the spongiform degeneration in prion diseases

Brain‐matter vacuolation is a defining trait of all prion diseases, yet its cause is unknown. Here, we report that prion infection and prion‐mimetic antibodies deplete the phosphoinositide kinase PIKfyve—which controls endolysosomal maturation—from mouse brains, cultured cells, organotypic brain sli...

Descripción completa

Detalles Bibliográficos
Autores principales: Lakkaraju, Asvin K K, Frontzek, Karl, Lemes, Emina, Herrmann, Uli, Losa, Marco, Marpakwar, Rajlakshmi, Aguzzi, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518562/
https://www.ncbi.nlm.nih.gov/pubmed/34291577
http://dx.doi.org/10.15252/emmm.202114714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518562/
https://www.ncbi.nlm.nih.gov/pubmed/34291577
http://dx.doi.org/10.15252/emmm.202114714

Ejemplares similares