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Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial
OBJECTIVE: The aim of this study was to determine whether a Mediterranean‐style, ketogenic diet mobile health application (app) with breath acetone biofeedback is superior to a calorie‐restricted, low‐fat diet app in promoting weight loss. METHODS: Participants (n = 155) with overweight/obesity (mea...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518592/ https://www.ncbi.nlm.nih.gov/pubmed/34124856 http://dx.doi.org/10.1002/oby.23242 |
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author | Falkenhain, Kaja Locke, Sean R. Lowe, Dylan A. Reitsma, Nicholas J. Lee, Terry Singer, Joel Weiss, Ethan J. Little, Jonathan P. |
author_facet | Falkenhain, Kaja Locke, Sean R. Lowe, Dylan A. Reitsma, Nicholas J. Lee, Terry Singer, Joel Weiss, Ethan J. Little, Jonathan P. |
author_sort | Falkenhain, Kaja |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to determine whether a Mediterranean‐style, ketogenic diet mobile health application (app) with breath acetone biofeedback is superior to a calorie‐restricted, low‐fat diet app in promoting weight loss. METHODS: Participants (n = 155) with overweight/obesity (mean [SD]: age 41 [11] years, BMI = 34 [5] kg/m(2), 71% female) were randomized to one of the interventions delivered entirely via app. Participants received a wireless scale and were instructed to take daily weight measurements. A third‐party laboratory collected blood samples at baseline and 12 weeks. RESULTS: Weight loss at 12 weeks was greater in the ketogenic (−5.6 kg; 95% CI: −6.7 kg to −4.5 kg) compared with the low‐fat group (−2.5 kg; 95% CI: −3.6 kg to −1.4 kg) (between‐group difference: −3.1 kg; 95% CI: −4.6 kg to −1.5 kg; p < 0.001). Weight loss at 24 weeks indicated durability of the effect (between‐group difference: −5.5 kg; 95% CI: −8.3 kg to −2.8 kg; p < 0.001). Secondary/exploratory outcomes of hemoglobin A1c and liver enzymes were improved to a greater extent in the ketogenic diet group (p < 0.01). CONCLUSIONS: Among adults with overweight/obesity, a ketogenic diet app with breath acetone biofeedback was superior to a calorie‐restricted diet app at promoting weight loss in a real‐world setting. |
format | Online Article Text |
id | pubmed-8518592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85185922021-10-21 Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial Falkenhain, Kaja Locke, Sean R. Lowe, Dylan A. Reitsma, Nicholas J. Lee, Terry Singer, Joel Weiss, Ethan J. Little, Jonathan P. Obesity (Silver Spring) ORIGINAL ARTICLES OBJECTIVE: The aim of this study was to determine whether a Mediterranean‐style, ketogenic diet mobile health application (app) with breath acetone biofeedback is superior to a calorie‐restricted, low‐fat diet app in promoting weight loss. METHODS: Participants (n = 155) with overweight/obesity (mean [SD]: age 41 [11] years, BMI = 34 [5] kg/m(2), 71% female) were randomized to one of the interventions delivered entirely via app. Participants received a wireless scale and were instructed to take daily weight measurements. A third‐party laboratory collected blood samples at baseline and 12 weeks. RESULTS: Weight loss at 12 weeks was greater in the ketogenic (−5.6 kg; 95% CI: −6.7 kg to −4.5 kg) compared with the low‐fat group (−2.5 kg; 95% CI: −3.6 kg to −1.4 kg) (between‐group difference: −3.1 kg; 95% CI: −4.6 kg to −1.5 kg; p < 0.001). Weight loss at 24 weeks indicated durability of the effect (between‐group difference: −5.5 kg; 95% CI: −8.3 kg to −2.8 kg; p < 0.001). Secondary/exploratory outcomes of hemoglobin A1c and liver enzymes were improved to a greater extent in the ketogenic diet group (p < 0.01). CONCLUSIONS: Among adults with overweight/obesity, a ketogenic diet app with breath acetone biofeedback was superior to a calorie‐restricted diet app at promoting weight loss in a real‐world setting. John Wiley and Sons Inc. 2021-09-14 2021-10 /pmc/articles/PMC8518592/ /pubmed/34124856 http://dx.doi.org/10.1002/oby.23242 Text en © 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS). https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | ORIGINAL ARTICLES Falkenhain, Kaja Locke, Sean R. Lowe, Dylan A. Reitsma, Nicholas J. Lee, Terry Singer, Joel Weiss, Ethan J. Little, Jonathan P. Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial |
title | Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial |
title_full | Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial |
title_fullStr | Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial |
title_full_unstemmed | Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial |
title_short | Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial |
title_sort | keyto app and device versus ww app on weight loss and metabolic risk in adults with overweight or obesity: a randomized trial |
topic | ORIGINAL ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518592/ https://www.ncbi.nlm.nih.gov/pubmed/34124856 http://dx.doi.org/10.1002/oby.23242 |
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