A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma

PURPOSE: To construct a prognosis model of melanoma based on pyroptosis related genes. METHODS: Melanoma RNA-sequencing data was downloaded from TCGA. First, the lnRNAs related to pyroptosis were obtained through Pearson correlation analysis. Then, the prognosis model of pyroptosis related genes was...

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Autores principales: Xie, Jiaheng, Li, Haobo, Chen, Liang, Cao, Yuan, Hu, Yiming, Zhu, Zhechen, Wang, Ming, Shi, Jingping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518699/
https://www.ncbi.nlm.nih.gov/pubmed/34675619
http://dx.doi.org/10.2147/IJGM.S335396
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author Xie, Jiaheng
Li, Haobo
Chen, Liang
Cao, Yuan
Hu, Yiming
Zhu, Zhechen
Wang, Ming
Shi, Jingping
author_facet Xie, Jiaheng
Li, Haobo
Chen, Liang
Cao, Yuan
Hu, Yiming
Zhu, Zhechen
Wang, Ming
Shi, Jingping
author_sort Xie, Jiaheng
collection PubMed
description PURPOSE: To construct a prognosis model of melanoma based on pyroptosis related genes. METHODS: Melanoma RNA-sequencing data was downloaded from TCGA. First, the lnRNAs related to pyroptosis were obtained through Pearson correlation analysis. Then, the prognosis model of pyroptosis related genes was constructed by Cox regression and Lasso regression. Melanoma patients were divided into high-risk and low-risk groups by risk score, and the differences in prognosis and immune microenvironment between the two groups were explored. RESULTS: We found that the high-risk group had a significantly poorer prognosis, and different groups differed in immune infiltration, m6A methylation, and immune checkpoint. CONCLUSION: Our prognostic model can provide a reference for the study of pyroptosis in melanoma cells and provide a new idea for melanoma treatment.
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spelling pubmed-85186992021-10-20 A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma Xie, Jiaheng Li, Haobo Chen, Liang Cao, Yuan Hu, Yiming Zhu, Zhechen Wang, Ming Shi, Jingping Int J Gen Med Original Research PURPOSE: To construct a prognosis model of melanoma based on pyroptosis related genes. METHODS: Melanoma RNA-sequencing data was downloaded from TCGA. First, the lnRNAs related to pyroptosis were obtained through Pearson correlation analysis. Then, the prognosis model of pyroptosis related genes was constructed by Cox regression and Lasso regression. Melanoma patients were divided into high-risk and low-risk groups by risk score, and the differences in prognosis and immune microenvironment between the two groups were explored. RESULTS: We found that the high-risk group had a significantly poorer prognosis, and different groups differed in immune infiltration, m6A methylation, and immune checkpoint. CONCLUSION: Our prognostic model can provide a reference for the study of pyroptosis in melanoma cells and provide a new idea for melanoma treatment. Dove 2021-10-08 /pmc/articles/PMC8518699/ /pubmed/34675619 http://dx.doi.org/10.2147/IJGM.S335396 Text en © 2021 Xie et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Xie, Jiaheng
Li, Haobo
Chen, Liang
Cao, Yuan
Hu, Yiming
Zhu, Zhechen
Wang, Ming
Shi, Jingping
A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma
title A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma
title_full A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma
title_fullStr A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma
title_full_unstemmed A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma
title_short A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma
title_sort novel pyroptosis-related lncrna signature for predicting the prognosis of skin cutaneous melanoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518699/
https://www.ncbi.nlm.nih.gov/pubmed/34675619
http://dx.doi.org/10.2147/IJGM.S335396
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