Abortive HIV‐1 RNA induces pro‐IL‐1β maturation via protein kinase PKR and inflammasome activation in humans

The proinflammatory cytokine IL‐1β mediates high levels of immune activation observed during acute and chronic human immunodeficiency virus 1 (HIV‐1) infection. Little is known about the mechanisms that drive IL‐1β activation during HIV‐1 infection. Here, we have identified a crucial role for aborti...

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Detalles Bibliográficos
Autores principales: Stunnenberg, Melissa, van Hamme, John L., Trimp, Marjolein, Gringhuis, Sonja I., Geijtenbeek, Teunis B.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Immunity to infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518791/
https://www.ncbi.nlm.nih.gov/pubmed/34223639
http://dx.doi.org/10.1002/eji.202149275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518791/
https://www.ncbi.nlm.nih.gov/pubmed/34223639
http://dx.doi.org/10.1002/eji.202149275

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