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Feasibility of Velocity‐Selective Arterial Spin Labeling in Breast Cancer Patients for Noncontrast‐Enhanced Perfusion Imaging
BACKGROUND: Dynamic contrast‐enhanced (DCE) MRI is the most sensitive method for detection of breast cancer. However, due to high costs and retention of intravenously injected gadolinium‐based contrast agent, screening with DCE‐MRI is only recommended for patients who are at high risk for developing...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518819/ https://www.ncbi.nlm.nih.gov/pubmed/34121250 http://dx.doi.org/10.1002/jmri.27781 |
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author | Franklin, Suzanne L. Voormolen, Nora Bones, Isabell K. Korteweg, Tijmen Wasser, Martin N. J. M. Dankers, Henrike G. Cohen, Daniele van Stralen, Marijn Bos, Clemens van Osch, Matthias J. P. |
author_facet | Franklin, Suzanne L. Voormolen, Nora Bones, Isabell K. Korteweg, Tijmen Wasser, Martin N. J. M. Dankers, Henrike G. Cohen, Daniele van Stralen, Marijn Bos, Clemens van Osch, Matthias J. P. |
author_sort | Franklin, Suzanne L. |
collection | PubMed |
description | BACKGROUND: Dynamic contrast‐enhanced (DCE) MRI is the most sensitive method for detection of breast cancer. However, due to high costs and retention of intravenously injected gadolinium‐based contrast agent, screening with DCE‐MRI is only recommended for patients who are at high risk for developing breast cancer. Thus, a noncontrast‐enhanced alternative to DCE is desirable. PURPOSE: To investigate whether velocity selective arterial spin labeling (VS‐ASL) can be used to identify increased perfusion and vascularity within breast lesions compared to surrounding tissue. STUDY TYPE: Prospective. POPULATION: Eight breast cancer patients. FIELD STRENGTH/SEQUENCE: A 3 T; VS‐ASL with multislice single‐shot gradient‐echo echo‐planar‐imaging readout. ASSESSMENT: VS‐ASL scans were independently assessed by three radiologists, with 3–25 years of experience in breast radiology. Scans were scored on lesion visibility and artifacts, based on a 3‐point Likert scale. A score of 1 corresponded to “lesions being distinguishable from background” (lesion visibility), and “no or few artifacts visible, artifacts can be distinguished from blood signal” (artifact score). A distinction was made between mass and nonmass lesions (based on BI‐RADS lexicon), as assessed in the standard clinical exam. STATISTICAL TESTS: Intra‐class correlation coefficient (ICC) for interobserver agreement. RESULTS: The ICC was 0.77 for lesion visibility and 0.84 for the artifact score. Overall, mass lesions had a mean score of 1.27 on lesion visibility and 1.53 on the artifact score. Nonmass lesions had a mean score of 2.11 on lesion visibility and 2.11 on the artifact score. DATA CONCLUSION: We have demonstrated the technical feasibility of bilateral whole‐breast perfusion imaging using VS‐ASL in breast cancer patients. EVIDENCE LEVEL: 1 TECHNICAL EFFICACY: Stage 1 |
format | Online Article Text |
id | pubmed-8518819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85188192021-10-21 Feasibility of Velocity‐Selective Arterial Spin Labeling in Breast Cancer Patients for Noncontrast‐Enhanced Perfusion Imaging Franklin, Suzanne L. Voormolen, Nora Bones, Isabell K. Korteweg, Tijmen Wasser, Martin N. J. M. Dankers, Henrike G. Cohen, Daniele van Stralen, Marijn Bos, Clemens van Osch, Matthias J. P. J Magn Reson Imaging Research Articles BACKGROUND: Dynamic contrast‐enhanced (DCE) MRI is the most sensitive method for detection of breast cancer. However, due to high costs and retention of intravenously injected gadolinium‐based contrast agent, screening with DCE‐MRI is only recommended for patients who are at high risk for developing breast cancer. Thus, a noncontrast‐enhanced alternative to DCE is desirable. PURPOSE: To investigate whether velocity selective arterial spin labeling (VS‐ASL) can be used to identify increased perfusion and vascularity within breast lesions compared to surrounding tissue. STUDY TYPE: Prospective. POPULATION: Eight breast cancer patients. FIELD STRENGTH/SEQUENCE: A 3 T; VS‐ASL with multislice single‐shot gradient‐echo echo‐planar‐imaging readout. ASSESSMENT: VS‐ASL scans were independently assessed by three radiologists, with 3–25 years of experience in breast radiology. Scans were scored on lesion visibility and artifacts, based on a 3‐point Likert scale. A score of 1 corresponded to “lesions being distinguishable from background” (lesion visibility), and “no or few artifacts visible, artifacts can be distinguished from blood signal” (artifact score). A distinction was made between mass and nonmass lesions (based on BI‐RADS lexicon), as assessed in the standard clinical exam. STATISTICAL TESTS: Intra‐class correlation coefficient (ICC) for interobserver agreement. RESULTS: The ICC was 0.77 for lesion visibility and 0.84 for the artifact score. Overall, mass lesions had a mean score of 1.27 on lesion visibility and 1.53 on the artifact score. Nonmass lesions had a mean score of 2.11 on lesion visibility and 2.11 on the artifact score. DATA CONCLUSION: We have demonstrated the technical feasibility of bilateral whole‐breast perfusion imaging using VS‐ASL in breast cancer patients. EVIDENCE LEVEL: 1 TECHNICAL EFFICACY: Stage 1 John Wiley & Sons, Inc. 2021-06-13 2021-10 /pmc/articles/PMC8518819/ /pubmed/34121250 http://dx.doi.org/10.1002/jmri.27781 Text en © 2021 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC. on behalf of International Society for Magnetic Resonance in Medicine. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Franklin, Suzanne L. Voormolen, Nora Bones, Isabell K. Korteweg, Tijmen Wasser, Martin N. J. M. Dankers, Henrike G. Cohen, Daniele van Stralen, Marijn Bos, Clemens van Osch, Matthias J. P. Feasibility of Velocity‐Selective Arterial Spin Labeling in Breast Cancer Patients for Noncontrast‐Enhanced Perfusion Imaging |
title | Feasibility of Velocity‐Selective Arterial Spin Labeling in Breast Cancer Patients for Noncontrast‐Enhanced Perfusion Imaging |
title_full | Feasibility of Velocity‐Selective Arterial Spin Labeling in Breast Cancer Patients for Noncontrast‐Enhanced Perfusion Imaging |
title_fullStr | Feasibility of Velocity‐Selective Arterial Spin Labeling in Breast Cancer Patients for Noncontrast‐Enhanced Perfusion Imaging |
title_full_unstemmed | Feasibility of Velocity‐Selective Arterial Spin Labeling in Breast Cancer Patients for Noncontrast‐Enhanced Perfusion Imaging |
title_short | Feasibility of Velocity‐Selective Arterial Spin Labeling in Breast Cancer Patients for Noncontrast‐Enhanced Perfusion Imaging |
title_sort | feasibility of velocity‐selective arterial spin labeling in breast cancer patients for noncontrast‐enhanced perfusion imaging |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518819/ https://www.ncbi.nlm.nih.gov/pubmed/34121250 http://dx.doi.org/10.1002/jmri.27781 |
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