The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle‐down characterization of antibodies

Mass spectrometry is gaining momentum as a method of choice to de novo sequence antibodies (Abs). Adequate sequence coverage of the hypervariable regions remains one of the toughest identification challenges by either bottom‐up or top‐down workflows. Methods that efficiently generate mid‐size Ab fra...

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Detalles Bibliográficos
Autores principales: Čaval, Tomislav, Hecht, Elizabeth Sara, Tang, Wilfred, Uy‐Gomez, Maelia, Nichols, Andrew, Kil, Yong J., Sandoval, Wendy, Bern, Marshall, Heck, Albert J. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518856/
https://www.ncbi.nlm.nih.gov/pubmed/33713388
http://dx.doi.org/10.1111/febs.15813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518856/
https://www.ncbi.nlm.nih.gov/pubmed/33713388
http://dx.doi.org/10.1111/febs.15813

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