Enantio‐ and Regioselective Palladium(II)‐Catalyzed Dioxygenation of (Aza‐)Alkenols

An oxidative Pd‐catalyzed intra‐intermolecular dioxygenation of (aza‐)alkenols has been reported, with total regioselectivity. To study the stereoselectivity, different chiral ligands as well as different hypervalent‐iodine compounds have been compared. In particular, by using a C‐6 modified pyridin...

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Detalles Bibliográficos
Autores principales: Giofrè, Sabrina, Molteni, Letizia, Nava, Donatella, Lo Presti, Leonardo, Beccalli, Egle Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518864/
https://www.ncbi.nlm.nih.gov/pubmed/34387928
http://dx.doi.org/10.1002/anie.202109312
Descripción
Sumario:An oxidative Pd‐catalyzed intra‐intermolecular dioxygenation of (aza‐)alkenols has been reported, with total regioselectivity. To study the stereoselectivity, different chiral ligands as well as different hypervalent‐iodine compounds have been compared. In particular, by using a C‐6 modified pyridinyl‐oxazoline (Pyox) ligand and hypervalent iodine bearing an aromatic ring, an excellent enantio‐ and diastereoselectivity has been achieved.

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