Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis

OBJECTIVE: We aimed to determine in relapsing multiple sclerosis (MS) whether intrathecal synthesis of immunoglobulin (Ig) M and IgG is associated with outcomes reflecting inflammatory activity and chronic worsening. METHODS: We compared cerebrospinal fluid analysis, clinical and magnetic resonance...

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Detalles Bibliográficos
Autores principales: Oechtering, Johanna, Schaedelin, Sabine, Benkert, Pascal, Müller, Stefanie, Achtnichts, Lutz, Vehoff, Jochen, Disanto, Giulio, Findling, Oliver, Fischer‐Barnicol, Bettina, Orleth, Annette, Chan, Andrew, Pot, Caroline, Barakovic, Muhamed, Rahmanzadeh, Reza, Galbusera, Riccardo, Heijnen, Ingmar, Lalive, Patrice H., Wuerfel, Jens, Subramaniam, Suvitha, Aeschbacher, Stefanie, Conen, David, Naegelin, Yvonne, Maceski, Aleksandra, Meier, Stephanie, Berger, Klaus, Wiendl, Heinz, Lincke, Therese, Lieb, Johanna, Yaldizli, Özgür, Sinnecker, Tim, Derfuss, Tobias, Regeniter, Axel, Zecca, Chiara, Gobbi, Claudio, Kappos, Ludwig, Granziera, Cristina, Leppert, David, Kuhle, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518907/
https://www.ncbi.nlm.nih.gov/pubmed/34057235
http://dx.doi.org/10.1002/ana.26137

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