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Design, Synthesis, Evaluation and Structure of Allenic 1α,25‐Dihydroxyvitamin D(3) Analogs with Locked Mobility at C‐17

Vitamin D receptor ligands have potential for the treatment of hyperproliferative diseases and disorders related to the immune system. However, hypercalcemic effects limit their therapeutical uses and call for the development of tissue‐selective new analogs. We have designed and synthesized the firs...

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Detalles Bibliográficos
Autores principales: Fraga, Ramón, Len, Kateryna, Lutzing, Regis, Laverny, Gilles, Loureiro, Julian, Maestro, Miguel A., Rochel, Natacha, Rodriguez‐Borges, Enrique, Mouriño, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519077/
https://www.ncbi.nlm.nih.gov/pubmed/34224173
http://dx.doi.org/10.1002/chem.202101578
Descripción
Sumario:Vitamin D receptor ligands have potential for the treatment of hyperproliferative diseases and disorders related to the immune system. However, hypercalcemic effects limit their therapeutical uses and call for the development of tissue‐selective new analogs. We have designed and synthesized the first examples of 1α,25‐dihydroxyvitamin D(3) analogs bearing an allenic unit attached to the D ring to restrict the side‐chain conformational mobility. The triene system was constructed by a Pd(0)‐mediated cyclization/Suzuki‐Miyaura cross‐coupling process in the presence of an allenic side chain. The allenic moiety was built through an orthoester‐Claisen rearrangement of a propargylic alcohol. The biological activity and structure of (22S)‐1α,25‐dihydroxy‐17,20‐dien‐24‐homo‐21‐nor‐vitamin D(3) bound to binding domain of the vitamin D receptor, provide information concerning side‐chain conformational requirements for biological activity.