Cargando…
Design, Synthesis, Evaluation and Structure of Allenic 1α,25‐Dihydroxyvitamin D(3) Analogs with Locked Mobility at C‐17
Vitamin D receptor ligands have potential for the treatment of hyperproliferative diseases and disorders related to the immune system. However, hypercalcemic effects limit their therapeutical uses and call for the development of tissue‐selective new analogs. We have designed and synthesized the firs...
Autores principales: | Fraga, Ramón, Len, Kateryna, Lutzing, Regis, Laverny, Gilles, Loureiro, Julian, Maestro, Miguel A., Rochel, Natacha, Rodriguez‐Borges, Enrique, Mouriño, Antonio |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519077/ https://www.ncbi.nlm.nih.gov/pubmed/34224173 http://dx.doi.org/10.1002/chem.202101578 |
Ejemplares similares
-
Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants
por: Belorusova, Anna Y., et al.
Publicado: (2022) -
Single-cell analyses unravel cell type–specific responses to a vitamin D analog in prostatic precancerous lesions
por: Abu el Maaty, Mohamed A., et al.
Publicado: (2021) -
26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D(3) (1,25D-d(6)) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines
por: Seoane, Samuel, et al.
Publicado: (2013) -
Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptorγ
por: Chebaro, Yassmine, et al.
Publicado: (2017) -
Carborane-based design of a potent vitamin D receptor agonist
por: Otero, Rocio, et al.
Publicado: (2016)