Brain amyloid burden, sleep, and 24-hour rest/activity rhythms: screening findings from the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration Studies

STUDY OBJECTIVES: To examine in a subsample at the screening phase of a clinical trial of a β-amyloid (Aβ) antibody whether disturbed sleep and altered 24-hour rest/activity rhythms (RARs) may serve as markers of preclinical Alzheimer’s disease (AD). METHODS: Overall, 26 Aβ-positive (Aβ+) and 33 Aβ-...

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Detalles Bibliográficos
Autores principales: Spira, Adam P, Zipunnikov, Vadim, Raman, Rema, Choi, Jiyoon, Di, Junrui, Bai, Jiawei, Carlsson, Cynthia M, Mintzer, Jacobo E, Marshall, Gad A, Porsteinsson, Anton P, Yaari, Roy, Wanigatunga, Sarah K, Kim, John, Wu, Mark N, Aisen, Paul S, Sperling, Reisa A, Rosenberg, Paul B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519157/
https://www.ncbi.nlm.nih.gov/pubmed/34661109
http://dx.doi.org/10.1093/sleepadvances/zpab015

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