Cargando…
The prevalence and clinical implications of pancreatic fat accumulation identified during a medical check-up
Fatty pancreas (FP) is characterized by pancreatic fat accumulation and the subsequent development of pancreatic and metabolic complications. However, FP has not been categorized in the manual for abdominal ultrasound in cancer screening and health check-ups in Japan, and the pathology of FP has not...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519203/ https://www.ncbi.nlm.nih.gov/pubmed/34731128 http://dx.doi.org/10.1097/MD.0000000000027487 |
_version_ | 1784584402274091008 |
---|---|
author | Okada, Kosuke Watahiki, Takahisa Horie, Kaoru Takayama, Takako Aida, Yuka To, Keii Shida, Takashi Ishige, Kazunori Nishiyama, Hiroyuki Shoda, Junichi Suzuki, Hideo |
author_facet | Okada, Kosuke Watahiki, Takahisa Horie, Kaoru Takayama, Takako Aida, Yuka To, Keii Shida, Takashi Ishige, Kazunori Nishiyama, Hiroyuki Shoda, Junichi Suzuki, Hideo |
author_sort | Okada, Kosuke |
collection | PubMed |
description | Fatty pancreas (FP) is characterized by pancreatic fat accumulation and the subsequent development of pancreatic and metabolic complications. However, FP has not been categorized in the manual for abdominal ultrasound in cancer screening and health check-ups in Japan, and the pathology of FP has not been fully elucidated. Nine hundred and nineteen people who underwent a medical check-up had the severity of their pancreatic fat accumulation categorized after transabdominal ultrasonographic examination. The relationships between FP, lifestyle-related diseases, and fatty liver disease at this time were assessed using stratification analysis. The prevalence of FP was 46.8% (430/919). People with FP were more likely to be male and had higher prevalences of lifestyle-related diseases, including fatty liver disease. Men and women were similarly represented in each tertile of pancreas brightness. Older age; high waist circumference, triglyceride and glucose index, serum low-density lipoprotein-cholesterol, hepatic steatosis index; and low serum amylase were associated with the presence of severe FP. Moreover, the group with severe liver steatosis had a higher prevalence of FP and a higher pancreatic brightness score. Logistic regression analysis showed that individuals with liver steatosis were more likely to have severe FP. The severity of FP is associated with features of lifestyle-related diseases and the severity of liver steatosis. These findings suggest that high visceral fat content is associated with more severe fatty pancreas as a phenotype of ectopic fat accumulation, as well as fatty liver disease. |
format | Online Article Text |
id | pubmed-8519203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-85192032021-10-18 The prevalence and clinical implications of pancreatic fat accumulation identified during a medical check-up Okada, Kosuke Watahiki, Takahisa Horie, Kaoru Takayama, Takako Aida, Yuka To, Keii Shida, Takashi Ishige, Kazunori Nishiyama, Hiroyuki Shoda, Junichi Suzuki, Hideo Medicine (Baltimore) 4500 Fatty pancreas (FP) is characterized by pancreatic fat accumulation and the subsequent development of pancreatic and metabolic complications. However, FP has not been categorized in the manual for abdominal ultrasound in cancer screening and health check-ups in Japan, and the pathology of FP has not been fully elucidated. Nine hundred and nineteen people who underwent a medical check-up had the severity of their pancreatic fat accumulation categorized after transabdominal ultrasonographic examination. The relationships between FP, lifestyle-related diseases, and fatty liver disease at this time were assessed using stratification analysis. The prevalence of FP was 46.8% (430/919). People with FP were more likely to be male and had higher prevalences of lifestyle-related diseases, including fatty liver disease. Men and women were similarly represented in each tertile of pancreas brightness. Older age; high waist circumference, triglyceride and glucose index, serum low-density lipoprotein-cholesterol, hepatic steatosis index; and low serum amylase were associated with the presence of severe FP. Moreover, the group with severe liver steatosis had a higher prevalence of FP and a higher pancreatic brightness score. Logistic regression analysis showed that individuals with liver steatosis were more likely to have severe FP. The severity of FP is associated with features of lifestyle-related diseases and the severity of liver steatosis. These findings suggest that high visceral fat content is associated with more severe fatty pancreas as a phenotype of ectopic fat accumulation, as well as fatty liver disease. Lippincott Williams & Wilkins 2021-10-15 /pmc/articles/PMC8519203/ /pubmed/34731128 http://dx.doi.org/10.1097/MD.0000000000027487 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 4500 Okada, Kosuke Watahiki, Takahisa Horie, Kaoru Takayama, Takako Aida, Yuka To, Keii Shida, Takashi Ishige, Kazunori Nishiyama, Hiroyuki Shoda, Junichi Suzuki, Hideo The prevalence and clinical implications of pancreatic fat accumulation identified during a medical check-up |
title | The prevalence and clinical implications of pancreatic fat accumulation identified during a medical check-up |
title_full | The prevalence and clinical implications of pancreatic fat accumulation identified during a medical check-up |
title_fullStr | The prevalence and clinical implications of pancreatic fat accumulation identified during a medical check-up |
title_full_unstemmed | The prevalence and clinical implications of pancreatic fat accumulation identified during a medical check-up |
title_short | The prevalence and clinical implications of pancreatic fat accumulation identified during a medical check-up |
title_sort | prevalence and clinical implications of pancreatic fat accumulation identified during a medical check-up |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519203/ https://www.ncbi.nlm.nih.gov/pubmed/34731128 http://dx.doi.org/10.1097/MD.0000000000027487 |
work_keys_str_mv | AT okadakosuke theprevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT watahikitakahisa theprevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT horiekaoru theprevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT takayamatakako theprevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT aidayuka theprevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT tokeii theprevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT shidatakashi theprevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT ishigekazunori theprevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT nishiyamahiroyuki theprevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT shodajunichi theprevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT suzukihideo theprevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT okadakosuke prevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT watahikitakahisa prevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT horiekaoru prevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT takayamatakako prevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT aidayuka prevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT tokeii prevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT shidatakashi prevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT ishigekazunori prevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT nishiyamahiroyuki prevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT shodajunichi prevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup AT suzukihideo prevalenceandclinicalimplicationsofpancreaticfataccumulationidentifiedduringamedicalcheckup |