Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma

Diffuse large B cell lymphoma (DLBCL) is an aggressive disorder accounting for >30% of all lymphomas. Its prognosis is poor due to a high relapse rate. Spontaneous regression (SR) in DLBCL is rare, with only a few reported cases. Moreover, almost all of these were low-grade lymphomas with an aver...

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Autores principales: Furukawa, Yoshiki, Ando, Jun, Ando, Miki, Kinoshita, Shintaro, Edahiro, Yoko, Furuta, Takuya, Ohshima, Koichi, Komatsu, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JSLRT 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519247/
https://www.ncbi.nlm.nih.gov/pubmed/34193754
http://dx.doi.org/10.3960/jslrt.21002
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author Furukawa, Yoshiki
Ando, Jun
Ando, Miki
Kinoshita, Shintaro
Edahiro, Yoko
Furuta, Takuya
Ohshima, Koichi
Komatsu, Norio
author_facet Furukawa, Yoshiki
Ando, Jun
Ando, Miki
Kinoshita, Shintaro
Edahiro, Yoko
Furuta, Takuya
Ohshima, Koichi
Komatsu, Norio
author_sort Furukawa, Yoshiki
collection PubMed
description Diffuse large B cell lymphoma (DLBCL) is an aggressive disorder accounting for >30% of all lymphomas. Its prognosis is poor due to a high relapse rate. Spontaneous regression (SR) in DLBCL is rare, with only a few reported cases. Moreover, almost all of these were low-grade lymphomas with an average SR duration of 13 mo. As the cause of SR is unknown, there are many theories such as trauma, infection, medication, and an antitumor immune response. We present a patient with progressive DLBCL who demonstrated SR for >42 mo. Although treatment for lymphoma usually starts soon after diagnosis, insights into SR of lymphomas may lead to new treatment strategies.
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spelling pubmed-85192472021-10-28 Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma Furukawa, Yoshiki Ando, Jun Ando, Miki Kinoshita, Shintaro Edahiro, Yoko Furuta, Takuya Ohshima, Koichi Komatsu, Norio J Clin Exp Hematop Case Report Diffuse large B cell lymphoma (DLBCL) is an aggressive disorder accounting for >30% of all lymphomas. Its prognosis is poor due to a high relapse rate. Spontaneous regression (SR) in DLBCL is rare, with only a few reported cases. Moreover, almost all of these were low-grade lymphomas with an average SR duration of 13 mo. As the cause of SR is unknown, there are many theories such as trauma, infection, medication, and an antitumor immune response. We present a patient with progressive DLBCL who demonstrated SR for >42 mo. Although treatment for lymphoma usually starts soon after diagnosis, insights into SR of lymphomas may lead to new treatment strategies. JSLRT 2021-06-30 /pmc/articles/PMC8519247/ /pubmed/34193754 http://dx.doi.org/10.3960/jslrt.21002 Text en © 2021 by The Japanese Society for Lymphoreticular Tissue Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License.
spellingShingle Case Report
Furukawa, Yoshiki
Ando, Jun
Ando, Miki
Kinoshita, Shintaro
Edahiro, Yoko
Furuta, Takuya
Ohshima, Koichi
Komatsu, Norio
Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma
title Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma
title_full Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma
title_fullStr Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma
title_full_unstemmed Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma
title_short Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma
title_sort long-term spontaneous regression of stage iv diffuse large b-cell lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519247/
https://www.ncbi.nlm.nih.gov/pubmed/34193754
http://dx.doi.org/10.3960/jslrt.21002
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