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Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak

INTRODUCTION: The World Health Organization (WHO) identified a novel coronavirus, originating in Wuhan, China, in December 2019, as a pneumonia causing pathogen. Epidemiological data in Romania show more than 450.000 confirmed patients, with a constant number of approximately 10% admission in intens...

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Autores principales: Roman, Adina, Moldovan, Septimiu, Santini, Ario, Stoian, Mircea, Dobru, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519387/
https://www.ncbi.nlm.nih.gov/pubmed/34722924
http://dx.doi.org/10.2478/jccm-2021-0021
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author Roman, Adina
Moldovan, Septimiu
Santini, Ario
Stoian, Mircea
Dobru, Daniela
author_facet Roman, Adina
Moldovan, Septimiu
Santini, Ario
Stoian, Mircea
Dobru, Daniela
author_sort Roman, Adina
collection PubMed
description INTRODUCTION: The World Health Organization (WHO) identified a novel coronavirus, originating in Wuhan, China, in December 2019, as a pneumonia causing pathogen. Epidemiological data in Romania show more than 450.000 confirmed patients, with a constant number of approximately 10% admission in intensive care unit. METHOD: A retrospective, observational study was conducted from 1st March to 30th October 2020, comprising 657 patients, confirmed as having COVID-19, and who had been admitted to the intensive care unit of the Mures County Clinical Hospital, Tîrgu Mures, Romania, which had been designated as a support hospital during the pandemic. Patients who presented at admission or developed abnormal liver function tests in the first seven days of admission, were included in the study; patients with pre-existing liver disease, were excluded. RESULTS: The mean (SD) age of patients included in the study was 59.41 (14.66) years with a male: female ratio of 1.51:1. Survivor status, defined as patients discharged from the intensive care unit, was significantly associated with parameters such as age, leukocyte count, albumin level, glycaemia level (p<0.05 for all parameters.) CONCLUSIONS: Liver injury expressed through liver function tests cannot solely constitute a prognostic factor for COVID-19 patients, but its presence in critically ill patients should be further investigated and included in future guideline protocols.
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spelling pubmed-85193872021-10-28 Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak Roman, Adina Moldovan, Septimiu Santini, Ario Stoian, Mircea Dobru, Daniela J Crit Care Med (Targu Mures) Research Article INTRODUCTION: The World Health Organization (WHO) identified a novel coronavirus, originating in Wuhan, China, in December 2019, as a pneumonia causing pathogen. Epidemiological data in Romania show more than 450.000 confirmed patients, with a constant number of approximately 10% admission in intensive care unit. METHOD: A retrospective, observational study was conducted from 1st March to 30th October 2020, comprising 657 patients, confirmed as having COVID-19, and who had been admitted to the intensive care unit of the Mures County Clinical Hospital, Tîrgu Mures, Romania, which had been designated as a support hospital during the pandemic. Patients who presented at admission or developed abnormal liver function tests in the first seven days of admission, were included in the study; patients with pre-existing liver disease, were excluded. RESULTS: The mean (SD) age of patients included in the study was 59.41 (14.66) years with a male: female ratio of 1.51:1. Survivor status, defined as patients discharged from the intensive care unit, was significantly associated with parameters such as age, leukocyte count, albumin level, glycaemia level (p<0.05 for all parameters.) CONCLUSIONS: Liver injury expressed through liver function tests cannot solely constitute a prognostic factor for COVID-19 patients, but its presence in critically ill patients should be further investigated and included in future guideline protocols. Sciendo 2021-08-05 /pmc/articles/PMC8519387/ /pubmed/34722924 http://dx.doi.org/10.2478/jccm-2021-0021 Text en © 2021 Adina Roman, Septimiu Moldovan, Ario Santini, Mircea Stoian, Daniela Dobru, published by Sciendo https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Research Article
Roman, Adina
Moldovan, Septimiu
Santini, Ario
Stoian, Mircea
Dobru, Daniela
Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak
title Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak
title_full Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak
title_fullStr Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak
title_full_unstemmed Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak
title_short Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak
title_sort impact of the severity of liver injury in covid-19 patients admitted to an intensive care unit during the sars-cov2 pandemic outbreak
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519387/
https://www.ncbi.nlm.nih.gov/pubmed/34722924
http://dx.doi.org/10.2478/jccm-2021-0021
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