Cargando…
The Importance of Iron Administration in Correcting Anaemia After Major Surgery
INTRODUCTION: Postoperative anaemia can affect more than 90% of patients undergoing major surgeries. Patients develop an absolute iron deficiency in the face of significant blood loss or preoperative anaemia and major surgery. Studies have shown the negative impact of these factors on transfusion re...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519388/ https://www.ncbi.nlm.nih.gov/pubmed/34722921 http://dx.doi.org/10.2478/jccm-2021-0028 |
_version_ | 1784584438209839104 |
---|---|
author | Tiglis, Mirela Cobilinschi, Cristian Elena Mirea, Liliana Emil Băetu, Alexandru Peride, Ileana Paul Neagu, Tiberiu Niculae, Andrei Alexandru Checherită, Ionel Marina Grintescu, Ioana |
author_facet | Tiglis, Mirela Cobilinschi, Cristian Elena Mirea, Liliana Emil Băetu, Alexandru Peride, Ileana Paul Neagu, Tiberiu Niculae, Andrei Alexandru Checherită, Ionel Marina Grintescu, Ioana |
author_sort | Tiglis, Mirela |
collection | PubMed |
description | INTRODUCTION: Postoperative anaemia can affect more than 90% of patients undergoing major surgeries. Patients develop an absolute iron deficiency in the face of significant blood loss or preoperative anaemia and major surgery. Studies have shown the negative impact of these factors on transfusion requirements, infections, increased hospitalisation and long-term morbidities. AIM OF THE STUDY: The research was performed to determine the correlation between intravenous iron administration in the postoperative period and improved haemoglobin correction trend. MATERIAL AND METHODS: A prospective study was conducted to screen and treat iron deficiency in patients undergoing major surgery associated with significant bleeding. For iron deficiency anaemia screening, in the postoperative period, the following bioumoral parameters were assessed: haemoglobin, serum iron, transferrin saturation (TSAT), and ferritin, direct serum total iron-binding capacity (dTIBC), mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH). In addition, serum glucose, fibrinogen, urea, creatinine and lactate values were also collected. RESULTS: Twenty-one patients undergoing major surgeries (52,38% were emergency and 47,61% elective interventions) were included in the study. Iron deficiency, as defined by ferritin 100-300 μg/L along with transferrin saturation (TSAT) < 20 %, mean corpuscular volume (MVC) < 92 fL, mean corpuscular haemoglobin (MCH) < 33 g/dL, serum iron < 10 μmol/L and direct serum total iron-binding capacity (dTIBC) > 36 μmol/L, was identified in all cases. To correct the deficit and optimise the haematological status, all patients received intravenous ferric carboxymaltose (500-1000 mg, single dose). Using Quadratic statistical analysis, the trend of haemoglobin correction was found to be a favourable one. CONCLUSION: The administration of intravenous ferric carboxymaltose in the postoperative period showed the beneficial effect of this type of intervention on the haemoglobin correction trend in these groups of patients. |
format | Online Article Text |
id | pubmed-8519388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-85193882021-10-28 The Importance of Iron Administration in Correcting Anaemia After Major Surgery Tiglis, Mirela Cobilinschi, Cristian Elena Mirea, Liliana Emil Băetu, Alexandru Peride, Ileana Paul Neagu, Tiberiu Niculae, Andrei Alexandru Checherită, Ionel Marina Grintescu, Ioana J Crit Care Med (Targu Mures) Research Article INTRODUCTION: Postoperative anaemia can affect more than 90% of patients undergoing major surgeries. Patients develop an absolute iron deficiency in the face of significant blood loss or preoperative anaemia and major surgery. Studies have shown the negative impact of these factors on transfusion requirements, infections, increased hospitalisation and long-term morbidities. AIM OF THE STUDY: The research was performed to determine the correlation between intravenous iron administration in the postoperative period and improved haemoglobin correction trend. MATERIAL AND METHODS: A prospective study was conducted to screen and treat iron deficiency in patients undergoing major surgery associated with significant bleeding. For iron deficiency anaemia screening, in the postoperative period, the following bioumoral parameters were assessed: haemoglobin, serum iron, transferrin saturation (TSAT), and ferritin, direct serum total iron-binding capacity (dTIBC), mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH). In addition, serum glucose, fibrinogen, urea, creatinine and lactate values were also collected. RESULTS: Twenty-one patients undergoing major surgeries (52,38% were emergency and 47,61% elective interventions) were included in the study. Iron deficiency, as defined by ferritin 100-300 μg/L along with transferrin saturation (TSAT) < 20 %, mean corpuscular volume (MVC) < 92 fL, mean corpuscular haemoglobin (MCH) < 33 g/dL, serum iron < 10 μmol/L and direct serum total iron-binding capacity (dTIBC) > 36 μmol/L, was identified in all cases. To correct the deficit and optimise the haematological status, all patients received intravenous ferric carboxymaltose (500-1000 mg, single dose). Using Quadratic statistical analysis, the trend of haemoglobin correction was found to be a favourable one. CONCLUSION: The administration of intravenous ferric carboxymaltose in the postoperative period showed the beneficial effect of this type of intervention on the haemoglobin correction trend in these groups of patients. Sciendo 2021-08-05 /pmc/articles/PMC8519388/ /pubmed/34722921 http://dx.doi.org/10.2478/jccm-2021-0028 Text en © 2021 Mirela Tiglis, Cristian Cobilinschi, Liliana Elena Mirea, Alexandru Emil Băetu, Ileana Peride, Tiberiu Paul Neagu, Andrei Niculae, Ionel Alexandru Checherită, Ioana Marina Grintescu, published by Sciendo https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Research Article Tiglis, Mirela Cobilinschi, Cristian Elena Mirea, Liliana Emil Băetu, Alexandru Peride, Ileana Paul Neagu, Tiberiu Niculae, Andrei Alexandru Checherită, Ionel Marina Grintescu, Ioana The Importance of Iron Administration in Correcting Anaemia After Major Surgery |
title | The Importance of Iron Administration in Correcting Anaemia After Major Surgery |
title_full | The Importance of Iron Administration in Correcting Anaemia After Major Surgery |
title_fullStr | The Importance of Iron Administration in Correcting Anaemia After Major Surgery |
title_full_unstemmed | The Importance of Iron Administration in Correcting Anaemia After Major Surgery |
title_short | The Importance of Iron Administration in Correcting Anaemia After Major Surgery |
title_sort | importance of iron administration in correcting anaemia after major surgery |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519388/ https://www.ncbi.nlm.nih.gov/pubmed/34722921 http://dx.doi.org/10.2478/jccm-2021-0028 |
work_keys_str_mv | AT tiglismirela theimportanceofironadministrationincorrectinganaemiaaftermajorsurgery AT cobilinschicristian theimportanceofironadministrationincorrectinganaemiaaftermajorsurgery AT elenamirealiliana theimportanceofironadministrationincorrectinganaemiaaftermajorsurgery AT emilbaetualexandru theimportanceofironadministrationincorrectinganaemiaaftermajorsurgery AT perideileana theimportanceofironadministrationincorrectinganaemiaaftermajorsurgery AT paulneagutiberiu theimportanceofironadministrationincorrectinganaemiaaftermajorsurgery AT niculaeandrei theimportanceofironadministrationincorrectinganaemiaaftermajorsurgery AT alexandruchecheritaionel theimportanceofironadministrationincorrectinganaemiaaftermajorsurgery AT marinagrintescuioana theimportanceofironadministrationincorrectinganaemiaaftermajorsurgery AT tiglismirela importanceofironadministrationincorrectinganaemiaaftermajorsurgery AT cobilinschicristian importanceofironadministrationincorrectinganaemiaaftermajorsurgery AT elenamirealiliana importanceofironadministrationincorrectinganaemiaaftermajorsurgery AT emilbaetualexandru importanceofironadministrationincorrectinganaemiaaftermajorsurgery AT perideileana importanceofironadministrationincorrectinganaemiaaftermajorsurgery AT paulneagutiberiu importanceofironadministrationincorrectinganaemiaaftermajorsurgery AT niculaeandrei importanceofironadministrationincorrectinganaemiaaftermajorsurgery AT alexandruchecheritaionel importanceofironadministrationincorrectinganaemiaaftermajorsurgery AT marinagrintescuioana importanceofironadministrationincorrectinganaemiaaftermajorsurgery |