The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif

Nontypeable Haemophilus influenzae (NTHi) is a significant pathogen in respiratory disease and otitis media. Important for NTHi survival, colonization and persistence in vivo is the Sap (sensitivity to antimicrobial peptides) ABC transporter system. Current models propose a direct role for Sap in he...

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Detalles Bibliográficos
Autores principales: Lukacik, Petra, Owen, C. David, Harris, Gemma, Bolla, Jani Reddy, Picaud, Sarah, Alibay, Irfan, Nettleship, Joanne E., Bird, Louise E., Owens, Raymond J., Biggin, Philip C., Filippakopoulos, Panagis, Robinson, Carol V., Walsh, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519434/
https://www.ncbi.nlm.nih.gov/pubmed/34653190
http://dx.doi.org/10.1371/journal.pone.0256070

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