Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation

CRISPR-based homing gene drives can be designed to disrupt essential genes whilst biasing their own inheritance, leading to suppression of mosquito populations in the laboratory. This class of gene drives relies on CRISPR-Cas9 cleavage of a target sequence and copying (‘homing’) therein of the gene...

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Detalles Bibliográficos
Autores principales: Fuchs, Silke, Garrood, William T., Beber, Anna, Hammond, Andrew, Galizi, Roberto, Gribble, Matthew, Morselli, Giulia, Hui, Tin-Yu J., Willis, Katie, Kranjc, Nace, Burt, Austin, Crisanti, Andrea, Nolan, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519452/
https://www.ncbi.nlm.nih.gov/pubmed/34610011
http://dx.doi.org/10.1371/journal.pgen.1009740

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