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Association between inter-leg blood pressure difference and cardiovascular outcome in patients undergoing percutaneous coronary intervention

BACKGROUND: Although the inter-arm blood pressure (BP) difference has been advocated to be associated with cardiovascular events, the implication of inter-leg BP difference has not been well established. This study was conducted to investigate whether inter-arm and -leg BP differences have prognosti...

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Autores principales: Moon, Inki, Kim, Hack-Lyoung, Lim, Woo-Hyun, Seo, Jae-Bin, Zo, Joo-Hee, Kim, Myung-A, Kim, Sang-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519463/
https://www.ncbi.nlm.nih.gov/pubmed/34653208
http://dx.doi.org/10.1371/journal.pone.0257443
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author Moon, Inki
Kim, Hack-Lyoung
Lim, Woo-Hyun
Seo, Jae-Bin
Zo, Joo-Hee
Kim, Myung-A
Kim, Sang-Hyun
author_facet Moon, Inki
Kim, Hack-Lyoung
Lim, Woo-Hyun
Seo, Jae-Bin
Zo, Joo-Hee
Kim, Myung-A
Kim, Sang-Hyun
author_sort Moon, Inki
collection PubMed
description BACKGROUND: Although the inter-arm blood pressure (BP) difference has been advocated to be associated with cardiovascular events, the implication of inter-leg BP difference has not been well established. This study was conducted to investigate whether inter-arm and -leg BP differences have prognostic value in patients undergoing percutaneous coronary intervention (PCI). METHODS: In this prospective study, we consecutively enrolled 667 patients who underwent PCI. Both arm and leg BPs were measured at the day after PCI. The primary outcome was a major adverse cardiovascular event (MACE) including cardiac death, acute coronary syndrome, coronary revascularization, stroke, and hospitalization for heart failure during the follow-up period. RESULTS: Mean age was 64.0±11.1 years old, and males were predominant (70.5%). During a mean follow-up period of 3.0 years, MACE occurred in 209 (31.3%) patients. The inter-leg systolic BP difference (ILSBPD) was significantly higher in patients with MACE than those without (9.9±12.3 vs. 7.2±7.5 mmHg, P = 0.004). The inter-arm systolic BP difference was not significantly different between patients with and without MACE (P = 0.403). In multivariable Cox regression analysis, increased ILSBPD was independently associated with the development of MACE (per 5 mmHg; hazard ratio, 1.07; 95% confidence interval, 1.01–1.14). The inter-arm systolic BP difference was not associated with MACE in the multivariable analysis. CONCLUSION: Increased ILSBPD was independently associated with worse cardiovascular outcomes after PCI. As ILSBPD is easy to measure, it may be helpful in the risk stratification of patients undergoing PCI.
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spelling pubmed-85194632021-10-16 Association between inter-leg blood pressure difference and cardiovascular outcome in patients undergoing percutaneous coronary intervention Moon, Inki Kim, Hack-Lyoung Lim, Woo-Hyun Seo, Jae-Bin Zo, Joo-Hee Kim, Myung-A Kim, Sang-Hyun PLoS One Research Article BACKGROUND: Although the inter-arm blood pressure (BP) difference has been advocated to be associated with cardiovascular events, the implication of inter-leg BP difference has not been well established. This study was conducted to investigate whether inter-arm and -leg BP differences have prognostic value in patients undergoing percutaneous coronary intervention (PCI). METHODS: In this prospective study, we consecutively enrolled 667 patients who underwent PCI. Both arm and leg BPs were measured at the day after PCI. The primary outcome was a major adverse cardiovascular event (MACE) including cardiac death, acute coronary syndrome, coronary revascularization, stroke, and hospitalization for heart failure during the follow-up period. RESULTS: Mean age was 64.0±11.1 years old, and males were predominant (70.5%). During a mean follow-up period of 3.0 years, MACE occurred in 209 (31.3%) patients. The inter-leg systolic BP difference (ILSBPD) was significantly higher in patients with MACE than those without (9.9±12.3 vs. 7.2±7.5 mmHg, P = 0.004). The inter-arm systolic BP difference was not significantly different between patients with and without MACE (P = 0.403). In multivariable Cox regression analysis, increased ILSBPD was independently associated with the development of MACE (per 5 mmHg; hazard ratio, 1.07; 95% confidence interval, 1.01–1.14). The inter-arm systolic BP difference was not associated with MACE in the multivariable analysis. CONCLUSION: Increased ILSBPD was independently associated with worse cardiovascular outcomes after PCI. As ILSBPD is easy to measure, it may be helpful in the risk stratification of patients undergoing PCI. Public Library of Science 2021-10-15 /pmc/articles/PMC8519463/ /pubmed/34653208 http://dx.doi.org/10.1371/journal.pone.0257443 Text en © 2021 Moon et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Moon, Inki
Kim, Hack-Lyoung
Lim, Woo-Hyun
Seo, Jae-Bin
Zo, Joo-Hee
Kim, Myung-A
Kim, Sang-Hyun
Association between inter-leg blood pressure difference and cardiovascular outcome in patients undergoing percutaneous coronary intervention
title Association between inter-leg blood pressure difference and cardiovascular outcome in patients undergoing percutaneous coronary intervention
title_full Association between inter-leg blood pressure difference and cardiovascular outcome in patients undergoing percutaneous coronary intervention
title_fullStr Association between inter-leg blood pressure difference and cardiovascular outcome in patients undergoing percutaneous coronary intervention
title_full_unstemmed Association between inter-leg blood pressure difference and cardiovascular outcome in patients undergoing percutaneous coronary intervention
title_short Association between inter-leg blood pressure difference and cardiovascular outcome in patients undergoing percutaneous coronary intervention
title_sort association between inter-leg blood pressure difference and cardiovascular outcome in patients undergoing percutaneous coronary intervention
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519463/
https://www.ncbi.nlm.nih.gov/pubmed/34653208
http://dx.doi.org/10.1371/journal.pone.0257443
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