Melatonin Suppresses Apoptosis of Nucleus Pulposus Cells through Inhibiting Autophagy via the PI3K/Akt Pathway in a High-Glucose Culture

Diabetes mellitus- (DM-) associated hyperglycemia promotes apoptosis of disc nucleus pulposus (NP) cells, which is a contributor to intervertebral disc degeneration (IDD). Melatonin is able to protect against cell apoptosis. However, its effects on apoptosis of NP cell in a high-glucose culture rema...

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Detalles Bibliográficos
Autores principales: Li, Jian, Wang, Chengqiang, Xue, Lixin, Zhang, Fan, Liu, Jianqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519679/
https://www.ncbi.nlm.nih.gov/pubmed/34660789
http://dx.doi.org/10.1155/2021/4604258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519679/
https://www.ncbi.nlm.nih.gov/pubmed/34660789
http://dx.doi.org/10.1155/2021/4604258

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