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A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia
Hepatitis C-induced mixed cryoglobulinemia leading to rapidly progressive gangrene, necessitating amputations, is a rare presentation. We describe a case of a 55-year-old man with untreated chronic hepatitis C virus (HCV) presenting with arthralgia and palpable purpura, which rapidly progressed to l...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519709/ https://www.ncbi.nlm.nih.gov/pubmed/34659845 http://dx.doi.org/10.1155/2021/8244432 |
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author | Khalid, Sameeha Alhankawi, Dhuha Kaur, Kamalmeet Ali, Ali Kazaryan, Anna Roytman, Marina |
author_facet | Khalid, Sameeha Alhankawi, Dhuha Kaur, Kamalmeet Ali, Ali Kazaryan, Anna Roytman, Marina |
author_sort | Khalid, Sameeha |
collection | PubMed |
description | Hepatitis C-induced mixed cryoglobulinemia leading to rapidly progressive gangrene, necessitating amputations, is a rare presentation. We describe a case of a 55-year-old man with untreated chronic hepatitis C virus (HCV) presenting with arthralgia and palpable purpura, which rapidly progressed to life-threatening gangrene of all extremities requiring amputations in the setting of mixed cryoglobulinemia. Treatment for HCV was initiated which led to the arrest of gangrene progression and the patient's survival. Patients with HCV-induced cryoglobulinemia should be closely monitored and started on early therapy with direct-acting antiviral therapy to prevent progression of vasculitis to gangrene. Universal screening for HCV can aid in early diagnosis and treatment to prevent devastating consequences. |
format | Online Article Text |
id | pubmed-8519709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-85197092021-10-16 A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia Khalid, Sameeha Alhankawi, Dhuha Kaur, Kamalmeet Ali, Ali Kazaryan, Anna Roytman, Marina Case Reports Hepatol Case Report Hepatitis C-induced mixed cryoglobulinemia leading to rapidly progressive gangrene, necessitating amputations, is a rare presentation. We describe a case of a 55-year-old man with untreated chronic hepatitis C virus (HCV) presenting with arthralgia and palpable purpura, which rapidly progressed to life-threatening gangrene of all extremities requiring amputations in the setting of mixed cryoglobulinemia. Treatment for HCV was initiated which led to the arrest of gangrene progression and the patient's survival. Patients with HCV-induced cryoglobulinemia should be closely monitored and started on early therapy with direct-acting antiviral therapy to prevent progression of vasculitis to gangrene. Universal screening for HCV can aid in early diagnosis and treatment to prevent devastating consequences. Hindawi 2021-10-08 /pmc/articles/PMC8519709/ /pubmed/34659845 http://dx.doi.org/10.1155/2021/8244432 Text en Copyright © 2021 Sameeha Khalid et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Khalid, Sameeha Alhankawi, Dhuha Kaur, Kamalmeet Ali, Ali Kazaryan, Anna Roytman, Marina A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia |
title | A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia |
title_full | A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia |
title_fullStr | A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia |
title_full_unstemmed | A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia |
title_short | A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia |
title_sort | devastating case of hepatitis c-induced mixed cryoglobulinemia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519709/ https://www.ncbi.nlm.nih.gov/pubmed/34659845 http://dx.doi.org/10.1155/2021/8244432 |
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