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A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia

Hepatitis C-induced mixed cryoglobulinemia leading to rapidly progressive gangrene, necessitating amputations, is a rare presentation. We describe a case of a 55-year-old man with untreated chronic hepatitis C virus (HCV) presenting with arthralgia and palpable purpura, which rapidly progressed to l...

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Autores principales: Khalid, Sameeha, Alhankawi, Dhuha, Kaur, Kamalmeet, Ali, Ali, Kazaryan, Anna, Roytman, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519709/
https://www.ncbi.nlm.nih.gov/pubmed/34659845
http://dx.doi.org/10.1155/2021/8244432
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author Khalid, Sameeha
Alhankawi, Dhuha
Kaur, Kamalmeet
Ali, Ali
Kazaryan, Anna
Roytman, Marina
author_facet Khalid, Sameeha
Alhankawi, Dhuha
Kaur, Kamalmeet
Ali, Ali
Kazaryan, Anna
Roytman, Marina
author_sort Khalid, Sameeha
collection PubMed
description Hepatitis C-induced mixed cryoglobulinemia leading to rapidly progressive gangrene, necessitating amputations, is a rare presentation. We describe a case of a 55-year-old man with untreated chronic hepatitis C virus (HCV) presenting with arthralgia and palpable purpura, which rapidly progressed to life-threatening gangrene of all extremities requiring amputations in the setting of mixed cryoglobulinemia. Treatment for HCV was initiated which led to the arrest of gangrene progression and the patient's survival. Patients with HCV-induced cryoglobulinemia should be closely monitored and started on early therapy with direct-acting antiviral therapy to prevent progression of vasculitis to gangrene. Universal screening for HCV can aid in early diagnosis and treatment to prevent devastating consequences.
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spelling pubmed-85197092021-10-16 A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia Khalid, Sameeha Alhankawi, Dhuha Kaur, Kamalmeet Ali, Ali Kazaryan, Anna Roytman, Marina Case Reports Hepatol Case Report Hepatitis C-induced mixed cryoglobulinemia leading to rapidly progressive gangrene, necessitating amputations, is a rare presentation. We describe a case of a 55-year-old man with untreated chronic hepatitis C virus (HCV) presenting with arthralgia and palpable purpura, which rapidly progressed to life-threatening gangrene of all extremities requiring amputations in the setting of mixed cryoglobulinemia. Treatment for HCV was initiated which led to the arrest of gangrene progression and the patient's survival. Patients with HCV-induced cryoglobulinemia should be closely monitored and started on early therapy with direct-acting antiviral therapy to prevent progression of vasculitis to gangrene. Universal screening for HCV can aid in early diagnosis and treatment to prevent devastating consequences. Hindawi 2021-10-08 /pmc/articles/PMC8519709/ /pubmed/34659845 http://dx.doi.org/10.1155/2021/8244432 Text en Copyright © 2021 Sameeha Khalid et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Khalid, Sameeha
Alhankawi, Dhuha
Kaur, Kamalmeet
Ali, Ali
Kazaryan, Anna
Roytman, Marina
A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia
title A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia
title_full A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia
title_fullStr A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia
title_full_unstemmed A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia
title_short A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia
title_sort devastating case of hepatitis c-induced mixed cryoglobulinemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519709/
https://www.ncbi.nlm.nih.gov/pubmed/34659845
http://dx.doi.org/10.1155/2021/8244432
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