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Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease
PURPOSE: Various studies have shown an association between miRNA polymorphisms and susceptibility to autoimmune disease (AD); however, the results are inconclusive. To evaluate whether miRNA polymorphisms account for a significant risk of AD, a total of 87 articles, including 39431 patients and 5670...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519726/ https://www.ncbi.nlm.nih.gov/pubmed/34659590 http://dx.doi.org/10.1155/2021/9978460 |
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author | Zhang, Jun Tan, Handan Cao, Qingfeng Su, Guannan Yang, Peizeng |
author_facet | Zhang, Jun Tan, Handan Cao, Qingfeng Su, Guannan Yang, Peizeng |
author_sort | Zhang, Jun |
collection | PubMed |
description | PURPOSE: Various studies have shown an association between miRNA polymorphisms and susceptibility to autoimmune disease (AD); however, the results are inconclusive. To evaluate whether miRNA polymorphisms account for a significant risk of AD, a total of 87 articles, including 39431 patients and 56708 controls, were identified to estimate their association with 12 AD subtypes. METHODS: Several electronic databases were searched to analyze population-based studies on the relationship between miRNA variants and AD risk. Fixed effects or random effect models were used in the meta-analysis for the risk assessment. RESULTS: In our meta-analysis, miR-146a rs2910164/rs57095329 conferred a marginally elevated risk for AD (allele model, OR = 1.08, 95% CI: 1.01-1.15, P = 0.019; allele model, OR = 1.09, 95 CI: 1.05-1.15, P < 0.001, respectively). Furthermore, miR-196a2 rs11614913 was also associated with AD risk (allele model, OR = 0.92, 95% CI: 0.88-0.97, P = 0.001) as well as miR-499 rs3746444 (allele model, OR = 1.16, 95% CI: 1.03-1.29, P = 0.011). In addition, associations were observed between miR-149 rs2292832/miR-27a rs895819 and AD susceptibility in the overall population (allele model, OR = 1.15, 95% CI: 1.06-1.24, P < 0.001; allele model, OR = 1.11, 95% CI:1.01-1.22, P = 0.043, respectively). CONCLUSIONS: Evidence from our systematic review suggests that miR-146a, miR-196a2, miR-499, miR-149, and miR-27a polymorphisms are associated with susceptibility to AD. |
format | Online Article Text |
id | pubmed-8519726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-85197262021-10-16 Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease Zhang, Jun Tan, Handan Cao, Qingfeng Su, Guannan Yang, Peizeng Dis Markers Research Article PURPOSE: Various studies have shown an association between miRNA polymorphisms and susceptibility to autoimmune disease (AD); however, the results are inconclusive. To evaluate whether miRNA polymorphisms account for a significant risk of AD, a total of 87 articles, including 39431 patients and 56708 controls, were identified to estimate their association with 12 AD subtypes. METHODS: Several electronic databases were searched to analyze population-based studies on the relationship between miRNA variants and AD risk. Fixed effects or random effect models were used in the meta-analysis for the risk assessment. RESULTS: In our meta-analysis, miR-146a rs2910164/rs57095329 conferred a marginally elevated risk for AD (allele model, OR = 1.08, 95% CI: 1.01-1.15, P = 0.019; allele model, OR = 1.09, 95 CI: 1.05-1.15, P < 0.001, respectively). Furthermore, miR-196a2 rs11614913 was also associated with AD risk (allele model, OR = 0.92, 95% CI: 0.88-0.97, P = 0.001) as well as miR-499 rs3746444 (allele model, OR = 1.16, 95% CI: 1.03-1.29, P = 0.011). In addition, associations were observed between miR-149 rs2292832/miR-27a rs895819 and AD susceptibility in the overall population (allele model, OR = 1.15, 95% CI: 1.06-1.24, P < 0.001; allele model, OR = 1.11, 95% CI:1.01-1.22, P = 0.043, respectively). CONCLUSIONS: Evidence from our systematic review suggests that miR-146a, miR-196a2, miR-499, miR-149, and miR-27a polymorphisms are associated with susceptibility to AD. Hindawi 2021-10-08 /pmc/articles/PMC8519726/ /pubmed/34659590 http://dx.doi.org/10.1155/2021/9978460 Text en Copyright © 2021 Jun Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Jun Tan, Handan Cao, Qingfeng Su, Guannan Yang, Peizeng Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease |
title | Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease |
title_full | Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease |
title_fullStr | Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease |
title_full_unstemmed | Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease |
title_short | Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease |
title_sort | meta-analysis of mirna variants associated with susceptibility to autoimmune disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519726/ https://www.ncbi.nlm.nih.gov/pubmed/34659590 http://dx.doi.org/10.1155/2021/9978460 |
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