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Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease

PURPOSE: Various studies have shown an association between miRNA polymorphisms and susceptibility to autoimmune disease (AD); however, the results are inconclusive. To evaluate whether miRNA polymorphisms account for a significant risk of AD, a total of 87 articles, including 39431 patients and 5670...

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Autores principales: Zhang, Jun, Tan, Handan, Cao, Qingfeng, Su, Guannan, Yang, Peizeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519726/
https://www.ncbi.nlm.nih.gov/pubmed/34659590
http://dx.doi.org/10.1155/2021/9978460
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author Zhang, Jun
Tan, Handan
Cao, Qingfeng
Su, Guannan
Yang, Peizeng
author_facet Zhang, Jun
Tan, Handan
Cao, Qingfeng
Su, Guannan
Yang, Peizeng
author_sort Zhang, Jun
collection PubMed
description PURPOSE: Various studies have shown an association between miRNA polymorphisms and susceptibility to autoimmune disease (AD); however, the results are inconclusive. To evaluate whether miRNA polymorphisms account for a significant risk of AD, a total of 87 articles, including 39431 patients and 56708 controls, were identified to estimate their association with 12 AD subtypes. METHODS: Several electronic databases were searched to analyze population-based studies on the relationship between miRNA variants and AD risk. Fixed effects or random effect models were used in the meta-analysis for the risk assessment. RESULTS: In our meta-analysis, miR-146a rs2910164/rs57095329 conferred a marginally elevated risk for AD (allele model, OR = 1.08, 95% CI: 1.01-1.15, P = 0.019; allele model, OR = 1.09, 95 CI: 1.05-1.15, P < 0.001, respectively). Furthermore, miR-196a2 rs11614913 was also associated with AD risk (allele model, OR = 0.92, 95% CI: 0.88-0.97, P = 0.001) as well as miR-499 rs3746444 (allele model, OR = 1.16, 95% CI: 1.03-1.29, P = 0.011). In addition, associations were observed between miR-149 rs2292832/miR-27a rs895819 and AD susceptibility in the overall population (allele model, OR = 1.15, 95% CI: 1.06-1.24, P < 0.001; allele model, OR = 1.11, 95% CI:1.01-1.22, P = 0.043, respectively). CONCLUSIONS: Evidence from our systematic review suggests that miR-146a, miR-196a2, miR-499, miR-149, and miR-27a polymorphisms are associated with susceptibility to AD.
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spelling pubmed-85197262021-10-16 Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease Zhang, Jun Tan, Handan Cao, Qingfeng Su, Guannan Yang, Peizeng Dis Markers Research Article PURPOSE: Various studies have shown an association between miRNA polymorphisms and susceptibility to autoimmune disease (AD); however, the results are inconclusive. To evaluate whether miRNA polymorphisms account for a significant risk of AD, a total of 87 articles, including 39431 patients and 56708 controls, were identified to estimate their association with 12 AD subtypes. METHODS: Several electronic databases were searched to analyze population-based studies on the relationship between miRNA variants and AD risk. Fixed effects or random effect models were used in the meta-analysis for the risk assessment. RESULTS: In our meta-analysis, miR-146a rs2910164/rs57095329 conferred a marginally elevated risk for AD (allele model, OR = 1.08, 95% CI: 1.01-1.15, P = 0.019; allele model, OR = 1.09, 95 CI: 1.05-1.15, P < 0.001, respectively). Furthermore, miR-196a2 rs11614913 was also associated with AD risk (allele model, OR = 0.92, 95% CI: 0.88-0.97, P = 0.001) as well as miR-499 rs3746444 (allele model, OR = 1.16, 95% CI: 1.03-1.29, P = 0.011). In addition, associations were observed between miR-149 rs2292832/miR-27a rs895819 and AD susceptibility in the overall population (allele model, OR = 1.15, 95% CI: 1.06-1.24, P < 0.001; allele model, OR = 1.11, 95% CI:1.01-1.22, P = 0.043, respectively). CONCLUSIONS: Evidence from our systematic review suggests that miR-146a, miR-196a2, miR-499, miR-149, and miR-27a polymorphisms are associated with susceptibility to AD. Hindawi 2021-10-08 /pmc/articles/PMC8519726/ /pubmed/34659590 http://dx.doi.org/10.1155/2021/9978460 Text en Copyright © 2021 Jun Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Jun
Tan, Handan
Cao, Qingfeng
Su, Guannan
Yang, Peizeng
Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease
title Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease
title_full Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease
title_fullStr Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease
title_full_unstemmed Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease
title_short Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease
title_sort meta-analysis of mirna variants associated with susceptibility to autoimmune disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519726/
https://www.ncbi.nlm.nih.gov/pubmed/34659590
http://dx.doi.org/10.1155/2021/9978460
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