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Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery

PURPOSE: Esophagectomy for cancer is an extensive procedure often followed by severe complications. This study investigated whether patients with severe symptoms of reflux are more likely to have sleep disturbances and reduced health-related quality of life (HRQL) after esophagectomy. METHODS: This...

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Autores principales: Lagergren, Pernilla, Johar, Asif, Rosenlund, Helen, Arnberg, Lars, Haglund, Lena, Ness-Jensen, Eivind, Schandl, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519838/
https://www.ncbi.nlm.nih.gov/pubmed/33502722
http://dx.doi.org/10.1007/s11764-020-00974-9
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author Lagergren, Pernilla
Johar, Asif
Rosenlund, Helen
Arnberg, Lars
Haglund, Lena
Ness-Jensen, Eivind
Schandl, Anna
author_facet Lagergren, Pernilla
Johar, Asif
Rosenlund, Helen
Arnberg, Lars
Haglund, Lena
Ness-Jensen, Eivind
Schandl, Anna
author_sort Lagergren, Pernilla
collection PubMed
description PURPOSE: Esophagectomy for cancer is an extensive procedure often followed by severe complications. This study investigated whether patients with severe symptoms of reflux are more likely to have sleep disturbances and reduced health-related quality of life (HRQL) after esophagectomy. METHODS: This Swedish nationwide prospective cohort study encompassed all patients who had undergone esophagectomy for cancer between 2013 and 2018. One year after surgery, the patients responded to three questionnaires on reflux (EORTC QLQOG25), sleep disturbances (KSQ), and HRQL (EORTC QLQ-C30). Multivariable logistic regression provided odds ratios (OR) with 95% confidence intervals (CI) for sleep disturbance/reduced HRQL between patients with and without reflux, adjusted for potential confounders. RESULTS: Among 241 esophagectomy patients, 66 (27%) reported severe reflux. Patients with reflux had an increased risk of sleep disturbances (OR 2.3, 95% CI: 1.3–4.3) compared to patients without reflux. More specifically, these patients were more likely to suffer from poor sleep quality (OR 4.9, 95% CI: 1.9–12.4). Patients with reflux and sleep disturbances reported reductions in global quality of life, role function, emotional function, social function, and more symptoms in all scales, except for dyspnea. CONCLUSIONS: This study suggests that patients with severe symptoms of reflux after esophagectomy have an increased risk of sleep disturbances and poor sleep quality, which in turn are associated with reduced HRQL. IMPLICATIONS FOR CANCER SURVIVORS: Alleviating reflux after oesophageal cancer surgery is important, since this common symptom might reduce HRQL and well-being.
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spelling pubmed-85198382021-10-29 Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery Lagergren, Pernilla Johar, Asif Rosenlund, Helen Arnberg, Lars Haglund, Lena Ness-Jensen, Eivind Schandl, Anna J Cancer Surviv Article PURPOSE: Esophagectomy for cancer is an extensive procedure often followed by severe complications. This study investigated whether patients with severe symptoms of reflux are more likely to have sleep disturbances and reduced health-related quality of life (HRQL) after esophagectomy. METHODS: This Swedish nationwide prospective cohort study encompassed all patients who had undergone esophagectomy for cancer between 2013 and 2018. One year after surgery, the patients responded to three questionnaires on reflux (EORTC QLQOG25), sleep disturbances (KSQ), and HRQL (EORTC QLQ-C30). Multivariable logistic regression provided odds ratios (OR) with 95% confidence intervals (CI) for sleep disturbance/reduced HRQL between patients with and without reflux, adjusted for potential confounders. RESULTS: Among 241 esophagectomy patients, 66 (27%) reported severe reflux. Patients with reflux had an increased risk of sleep disturbances (OR 2.3, 95% CI: 1.3–4.3) compared to patients without reflux. More specifically, these patients were more likely to suffer from poor sleep quality (OR 4.9, 95% CI: 1.9–12.4). Patients with reflux and sleep disturbances reported reductions in global quality of life, role function, emotional function, social function, and more symptoms in all scales, except for dyspnea. CONCLUSIONS: This study suggests that patients with severe symptoms of reflux after esophagectomy have an increased risk of sleep disturbances and poor sleep quality, which in turn are associated with reduced HRQL. IMPLICATIONS FOR CANCER SURVIVORS: Alleviating reflux after oesophageal cancer surgery is important, since this common symptom might reduce HRQL and well-being. Springer US 2021-01-27 2021 /pmc/articles/PMC8519838/ /pubmed/33502722 http://dx.doi.org/10.1007/s11764-020-00974-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lagergren, Pernilla
Johar, Asif
Rosenlund, Helen
Arnberg, Lars
Haglund, Lena
Ness-Jensen, Eivind
Schandl, Anna
Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery
title Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery
title_full Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery
title_fullStr Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery
title_full_unstemmed Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery
title_short Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery
title_sort severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519838/
https://www.ncbi.nlm.nih.gov/pubmed/33502722
http://dx.doi.org/10.1007/s11764-020-00974-9
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