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Association between kidney stones and risk of developing stroke: a meta-analysis

BACKGROUND: Many studies have described the relationship between kidney stones and stroke, but the results are controversial, so we conducted this meta-analysis to estimate the relationship between kidney stones and the risk of developing stroke. METHODS: Studies were marked with a comprehensive sea...

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Autores principales: Yuan, Min, Zhou, Huang-Yan, Hu, Fan, Liu, Shi-Ying, Rao, Wei, Wu, Ling-Feng, Nie, Hong-Bing, Cao, Wen-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519881/
https://www.ncbi.nlm.nih.gov/pubmed/33606128
http://dx.doi.org/10.1007/s10072-021-05113-5
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author Yuan, Min
Zhou, Huang-Yan
Hu, Fan
Liu, Shi-Ying
Rao, Wei
Wu, Ling-Feng
Nie, Hong-Bing
Cao, Wen-Feng
author_facet Yuan, Min
Zhou, Huang-Yan
Hu, Fan
Liu, Shi-Ying
Rao, Wei
Wu, Ling-Feng
Nie, Hong-Bing
Cao, Wen-Feng
author_sort Yuan, Min
collection PubMed
description BACKGROUND: Many studies have described the relationship between kidney stones and stroke, but the results are controversial, so we conducted this meta-analysis to estimate the relationship between kidney stones and the risk of developing stroke. METHODS: Studies were marked with a comprehensive search of PubMed, EMBASE, Google, and ISI Web of Science databases through 25 March 2020. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted, and a random-effects model or fix-effects model was used to compute the pooled combined risk estimate. Heterogeneity was reported as I(2). We performed subgroup and sensitivity analysis to assess potential sources of heterogeneity. RESULTS: Eight studies of seven articles involving 3,526,808 participants were included in the meta-analysis. Overall, kidney stones were associated with a moderate risk of stroke incidence (HR, 1.24; 95% CI, 1.11–1.40; I(2)=79.6%; p=0.000). We conducted a sensitivity analysis by removing the studies that had a high risk of bias. Heterogeneity subsequently decreased significantly, while an increased risk of stroke in patient with kidney stones was again demonstrated (HR, 1.16; 95% CI, 1.11–1.23; I(2)=28.7%; p=0.000). Stratifying analysis showed that the results were more pronounced for ischemic stroke (HR, 1.14; 95% CI, 1.08–1.22; I(2)=15.6%; p=0.00) and the follow-up duration ≥10 years (HR, 1.18; 95% CI, 1.10–1.27; I(2)=31.6%; p=0.003). CONCLUSIONS: Our meta-analysis suggests that patients with kidney stones may have a modestly increased risk of developing stroke, especially in ischemic stroke. More large-scaled and clinical trials should be done to identify the relative impact of kidney stones on stroke outcomes in the future. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10072-021-05113-5.
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spelling pubmed-85198812021-10-29 Association between kidney stones and risk of developing stroke: a meta-analysis Yuan, Min Zhou, Huang-Yan Hu, Fan Liu, Shi-Ying Rao, Wei Wu, Ling-Feng Nie, Hong-Bing Cao, Wen-Feng Neurol Sci Original Article BACKGROUND: Many studies have described the relationship between kidney stones and stroke, but the results are controversial, so we conducted this meta-analysis to estimate the relationship between kidney stones and the risk of developing stroke. METHODS: Studies were marked with a comprehensive search of PubMed, EMBASE, Google, and ISI Web of Science databases through 25 March 2020. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted, and a random-effects model or fix-effects model was used to compute the pooled combined risk estimate. Heterogeneity was reported as I(2). We performed subgroup and sensitivity analysis to assess potential sources of heterogeneity. RESULTS: Eight studies of seven articles involving 3,526,808 participants were included in the meta-analysis. Overall, kidney stones were associated with a moderate risk of stroke incidence (HR, 1.24; 95% CI, 1.11–1.40; I(2)=79.6%; p=0.000). We conducted a sensitivity analysis by removing the studies that had a high risk of bias. Heterogeneity subsequently decreased significantly, while an increased risk of stroke in patient with kidney stones was again demonstrated (HR, 1.16; 95% CI, 1.11–1.23; I(2)=28.7%; p=0.000). Stratifying analysis showed that the results were more pronounced for ischemic stroke (HR, 1.14; 95% CI, 1.08–1.22; I(2)=15.6%; p=0.00) and the follow-up duration ≥10 years (HR, 1.18; 95% CI, 1.10–1.27; I(2)=31.6%; p=0.003). CONCLUSIONS: Our meta-analysis suggests that patients with kidney stones may have a modestly increased risk of developing stroke, especially in ischemic stroke. More large-scaled and clinical trials should be done to identify the relative impact of kidney stones on stroke outcomes in the future. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10072-021-05113-5. Springer International Publishing 2021-02-19 2021 /pmc/articles/PMC8519881/ /pubmed/33606128 http://dx.doi.org/10.1007/s10072-021-05113-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Yuan, Min
Zhou, Huang-Yan
Hu, Fan
Liu, Shi-Ying
Rao, Wei
Wu, Ling-Feng
Nie, Hong-Bing
Cao, Wen-Feng
Association between kidney stones and risk of developing stroke: a meta-analysis
title Association between kidney stones and risk of developing stroke: a meta-analysis
title_full Association between kidney stones and risk of developing stroke: a meta-analysis
title_fullStr Association between kidney stones and risk of developing stroke: a meta-analysis
title_full_unstemmed Association between kidney stones and risk of developing stroke: a meta-analysis
title_short Association between kidney stones and risk of developing stroke: a meta-analysis
title_sort association between kidney stones and risk of developing stroke: a meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519881/
https://www.ncbi.nlm.nih.gov/pubmed/33606128
http://dx.doi.org/10.1007/s10072-021-05113-5
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