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Long-term stability predictions of therapeutic monoclonal antibodies in solution using Arrhenius-based kinetics

Long-term stability of monoclonal antibodies to be used as biologics is a key aspect in their development. Therefore, its possible early prediction from accelerated stability studies is of major interest, despite currently being regarded as not sufficiently robust. In this work, using a combination...

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Detalles Bibliográficos
Autores principales: Kuzman, Drago, Bunc, Marko, Ravnik, Miha, Reiter, Fritz, Žagar, Lan, Bončina, Matjaž
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519954/
https://www.ncbi.nlm.nih.gov/pubmed/34654882
http://dx.doi.org/10.1038/s41598-021-99875-9