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p27kip1 expression and phosphorylation dictate Palbociclib sensitivity in KRAS-mutated colorectal cancer

In colorectal cancer, mutation of KRAS (RAS(MUT)) reduces therapeutic options, negatively affecting prognosis of the patients. In this setting, administration of CDK4/6-inhibitors, alone or in combination with other drugs, is being tested as promising therapeutic strategy. Identifying sensitive pati...

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Detalles Bibliográficos
Autores principales:	Rampioni Vinciguerra, Gian Luca, Dall’Acqua, Alessandra, Segatto, Ilenia, Mattevi, Maria Chiara, Russo, Francesca, Favero, Andrea, Cirombella, Roberto, Mungo, Giorgia, Viotto, Davide, Karimbayli, Javad, Pesce, Margherita, Vecchione, Andrea, Belletti, Barbara, Baldassarre, Gustavo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519959/ https://www.ncbi.nlm.nih.gov/pubmed/34654798 http://dx.doi.org/10.1038/s41419-021-04241-2

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