Cargando…
Retinal diffusion restrictions in acute branch retinal arteriolar occlusion
This study sought to investigate the occurrence of retinal diffusion restrictions (RDR) in branch retinal arteriolar occlusion (BRAO) using standard brain diffusion-weighted imaging (DWI). Two radiologists assessed DWI MRI scans of BRAO patients for RDR in a retrospective cohort study. Inter- and in...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519991/ https://www.ncbi.nlm.nih.gov/pubmed/34654843 http://dx.doi.org/10.1038/s41598-021-00127-7 |
_version_ | 1784584570737262592 |
---|---|
author | Danyel, Leon Alexander Miszczuk, M. Villringer, K. Bohner, G. Siebert, E. |
author_facet | Danyel, Leon Alexander Miszczuk, M. Villringer, K. Bohner, G. Siebert, E. |
author_sort | Danyel, Leon Alexander |
collection | PubMed |
description | This study sought to investigate the occurrence of retinal diffusion restrictions (RDR) in branch retinal arteriolar occlusion (BRAO) using standard brain diffusion-weighted imaging (DWI). Two radiologists assessed DWI MRI scans of BRAO patients for RDR in a retrospective cohort study. Inter- and intrarater reliability were calculated using Kappa statistics. Detection rates of RDR were compared among MRI scans with varying field strength, sequence type and onset-to-DWI time intervals. 85 BRAO patients (63.1 ± 16.5 years) and 89 DWI scans were evaluated. Overall sensitivity of RDR in BRAO was 46.1% with visually correlating low ADC signal in 56.1% of cases. Localization of RDR matched distribution of fundoscopic retinal edema in 85% of patients. Inter- and intra-rater agreement for RDR in BRAO was κ(inter) = 0.64 (95% CI 0.48–0.80) and κ(intra) = 0.87 (95% CI 0.76–0.96), respectively. RDR detection rate tended to be higher for 3T, when compared to 1.5T MRI scans (53.7% vs. 34.3%%; p = 0.07). RDR were identified within 24 h up to 2 weeks after onset of visual impairment. RDR in BRAO can be observed by means of standard stroke DWI in a substantial proportion of cases, although sensitivity and interrater reliability were lower than previously reported for complete central retinal artery occlusion. |
format | Online Article Text |
id | pubmed-8519991 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85199912021-10-20 Retinal diffusion restrictions in acute branch retinal arteriolar occlusion Danyel, Leon Alexander Miszczuk, M. Villringer, K. Bohner, G. Siebert, E. Sci Rep Article This study sought to investigate the occurrence of retinal diffusion restrictions (RDR) in branch retinal arteriolar occlusion (BRAO) using standard brain diffusion-weighted imaging (DWI). Two radiologists assessed DWI MRI scans of BRAO patients for RDR in a retrospective cohort study. Inter- and intrarater reliability were calculated using Kappa statistics. Detection rates of RDR were compared among MRI scans with varying field strength, sequence type and onset-to-DWI time intervals. 85 BRAO patients (63.1 ± 16.5 years) and 89 DWI scans were evaluated. Overall sensitivity of RDR in BRAO was 46.1% with visually correlating low ADC signal in 56.1% of cases. Localization of RDR matched distribution of fundoscopic retinal edema in 85% of patients. Inter- and intra-rater agreement for RDR in BRAO was κ(inter) = 0.64 (95% CI 0.48–0.80) and κ(intra) = 0.87 (95% CI 0.76–0.96), respectively. RDR detection rate tended to be higher for 3T, when compared to 1.5T MRI scans (53.7% vs. 34.3%%; p = 0.07). RDR were identified within 24 h up to 2 weeks after onset of visual impairment. RDR in BRAO can be observed by means of standard stroke DWI in a substantial proportion of cases, although sensitivity and interrater reliability were lower than previously reported for complete central retinal artery occlusion. Nature Publishing Group UK 2021-10-15 /pmc/articles/PMC8519991/ /pubmed/34654843 http://dx.doi.org/10.1038/s41598-021-00127-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Danyel, Leon Alexander Miszczuk, M. Villringer, K. Bohner, G. Siebert, E. Retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
title | Retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
title_full | Retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
title_fullStr | Retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
title_full_unstemmed | Retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
title_short | Retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
title_sort | retinal diffusion restrictions in acute branch retinal arteriolar occlusion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519991/ https://www.ncbi.nlm.nih.gov/pubmed/34654843 http://dx.doi.org/10.1038/s41598-021-00127-7 |
work_keys_str_mv | AT danyelleonalexander retinaldiffusionrestrictionsinacutebranchretinalarteriolarocclusion AT miszczukm retinaldiffusionrestrictionsinacutebranchretinalarteriolarocclusion AT villringerk retinaldiffusionrestrictionsinacutebranchretinalarteriolarocclusion AT bohnerg retinaldiffusionrestrictionsinacutebranchretinalarteriolarocclusion AT sieberte retinaldiffusionrestrictionsinacutebranchretinalarteriolarocclusion |