Cargando…

Risk assessment of latent tuberculosis infection through a multiplexed cytokine biosensor assay and machine learning feature selection

Accurate detection and risk stratification of latent tuberculosis infection (LTBI) remains a major clinical and public health problem. We hypothesize that multiparameter strategies that probe immune responses to Mycobacterium tuberculosis can provide new diagnostic insights into not only the status...

Descripción completa

Detalles Bibliográficos
Autores principales:	Robison, Heather M., Chapman, Cole A., Zhou, Haowen, Erskine, Courtney L., Theel, Elitza, Peikert, Tobias, Lindestam Arlehamn, Cecilia S., Sette, Alessandro, Bushell, Colleen, Welge, Michael, Zhu, Ruoqing, Bailey, Ryan C., Escalante, Patricio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520014/ https://www.ncbi.nlm.nih.gov/pubmed/34654869 http://dx.doi.org/10.1038/s41598-021-99754-3

Ejemplares similares

Definition of CD4 Immunosignatures Associated with MTB
por: Lindestam Arlehamn, Cecilia S., et al.
Publicado: (2014)

Lack of evidence for BCG vaccine protection from severe COVID-19
por: Lindestam Arlehamn, Cecilia S., et al.
Publicado: (2020)

Antigen Specific Humoral and Cellular Immunity Following SARS-CoV-2 Vaccination in ANCA-Associated Vasculitis Patients Receiving B-Cell Depleting Therapy
por: Marty, Paige K., et al.
Publicado: (2022)

Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells
por: Garretti, Francesca, et al.
Publicado: (2019)

Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson’s Disease
por: Williams, Gregory P., et al.
Publicado: (2022)

Performance Characteristics of High-Throughput Serologic Assays for Severe Acute Respiratory Syndrome Coronavirus 2 with Food and Drug Administration Emergency Use Authorization: A Review
por: Theel, Elitza S.
Publicado: (2022)

Flow Cytometric Immune Profiling in Infliximab-Associated Tuberculosis
por: Pennington, Kelly, et al.
Publicado: (2017)

Classical CD4 T cells as the cornerstone of antimycobacterial immunity
por: Morgan, Jeffrey, et al.
Publicado: (2021)

Experimental validation of the RATE tool for inferring HLA restrictions of T cell epitopes
por: Paul, Sinu, et al.
Publicado: (2017)

Convalescent Adaptive Immunity is Highly Heterogenous after SARS-CoV-2 Infection
por: Marty, Paige K., et al.
Publicado: (2023)

Validation of a multiplex flow immunoassay for detection of IgG antibodies against SARS-CoV-2 in dried blood spots
por: Turgeon, Coleman T., et al.
Publicado: (2021)

Immunity to SARS-CoV-2: What Do We Know and Should We Be Testing for It?
por: Misra, Anisha, et al.
Publicado: (2022)

Pseudomonas aeruginosa pilin activates the inflammasome
por: Lindestam Arlehamn, Cecilia S, et al.
Publicado: (2011)

Automatic Generation of Validated Specific Epitope Sets
por: Carrasco Pro, Sebastian, et al.
Publicado: (2015)

Host Transcriptomics as a Tool to Identify Diagnostic and Mechanistic Immune Signatures of Tuberculosis
por: Burel, Julie G., et al.
Publicado: (2019)

The Challenge of Distinguishing Cell–Cell Complexes from Singlet Cells in Non‐Imaging Flow Cytometry and Single‐Cell Sorting
por: Burel, Julie G., et al.
Publicado: (2020)

Convalescent Adaptive Immunity Is Highly Heterogenous after SARS-CoV-2 Infection
por: Pathakumari, Balaji, et al.
Publicado: (2023)

Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice
por: Patankar, Yash R., et al.
Publicado: (2019)

Molecular and Direct Detection Tests for Treponema pallidum Subspecies pallidum: A Review of the Literature, 1964–2017
por: Theel, Elitza S, et al.
Publicado: (2020)

Serum Epitope Repertoire Analysis Enables Early Detection of Lyme Disease with Improved Sensitivity in an Expandable Multiplex Format
por: Reifert, Jack, et al.
Publicado: (2021)

Diagnostic Testing for Zika: Observing Rapid Translation During a Public Health Emergency
por: Kurani, Shaheen, et al.
Publicado: (2017)

Fecal Bacteria as Biomarkers for Predicting Food Intake in Healthy Adults
por: Shinn, Leila M, et al.
Publicado: (2020)

Anti-HIV potency of T-cell responses elicited by dendritic cell therapeutic vaccination
por: Surenaud, Mathieu, et al.
Publicado: (2019)

Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis
por: Du Bruyn, Elsa, et al.
Publicado: (2020)

Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3(+)CCR6(+) Th1 Subset
por: Lindestam Arlehamn, Cecilia S., et al.
Publicado: (2013)

Biofunctionalization of Multiplexed Silicon Photonic Biosensors
por: Puumala, Lauren S., et al.
Publicado: (2022)

Multiplex Portable Biosensor for Bacteria Detection
por: Kaci, Karim, et al.
Publicado: (2023)

Editorial: Exploring Immune Variability in Susceptibility to Tuberculosis Infection in Humans
por: Seshadri, Chetan, et al.
Publicado: (2022)

Imprinting of Gut-Homing Receptors on Mtb-Specific Th1* Cells Is Associated with Reduced Lung Homing after Gavage BCG Vaccination of Rhesus Macaques
por: Hoft, Stella G., et al.
Publicado: (2023)

Screening for SARS-CoV-2: Health Policy Implications in Low- and Middle-Income Countries
por: Hashmi, Shahrukh K., et al.
Publicado: (2020)

Performance Characteristics of Four High-Throughput Immunoassays for Detection of IgG Antibodies against SARS-CoV-2
por: Theel, Elitza S., et al.
Publicado: (2020)

339. Assessing Utilization of the Venereal Disease Research Laboratory Test in Cerebrospinal Fluid for the Diagnosis of Neurosyphilis: A Cohort Study
por: Sytsma, Terin, et al.
Publicado: (2020)

New Diagnostics to Infer Risk in Tuberculosis: Is the Term “Latent Tuberculosis Infection” Obsolete?
por: Escalante, Patricio, et al.
Publicado: (2021)

Disease extent and anti‐tubercular treatment response correlates with Mycobacterium tuberculosis‐specific CD4 T‐cell phenotype regardless of HIV‐1 status
por: Riou, Catherine, et al.
Publicado: (2020)

Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer
por: Miao, Ruizhong, et al.
Publicado: (2020)

Multicolor Fluorescent Biosensor for Multiplexed Detection of DNA
por: Hu, Rong, et al.
Publicado: (2014)

Biosensors for the Multiplex Detection of Inflammatory Disease Biomarkers
por: Mobasheri, Ali
Publicado: (2020)

The Role of Potassium in Inflammasome Activation by Bacteria
por: Arlehamn, Cecilia S. Lindestam, et al.
Publicado: (2010)

Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4(+) T Cell Responses
por: da Silva Antunes, Ricardo, et al.
Publicado: (2017)

Correction: Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4(+) T Cell Responses
por: da Silva Antunes, Ricardo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_04kdff3k2r4k9ovmpv303jjv7r