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Brd4 Inactivation Increases Adenoviral Delivery of BMP2 for Paracrine Stimulation of Osteogenic Differentiation as a Gene Therapeutic Concept to Enhance Bone Healing

Bromodomain (BRD) proteins are histone code interpreters that recognize acetylated lysines and link the dynamic state of chromatin with the transcriptional machinery. Here, we demonstrate that ablation of the Brd4 gene in primary mouse bone marrow–derived mesenchymal stem cells via a conditional Brd...

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Detalles Bibliográficos
Autores principales:	Paradise, Christopher R, De La Vega, Rodolfo E, Galvan, M Lizeth, Carrasco, Margarita E, Thaler, Roman, van Wijnen, Andre J, Dudakovic, Amel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520065/ https://www.ncbi.nlm.nih.gov/pubmed/34693189 http://dx.doi.org/10.1002/jbm4.10520

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