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Unilateral axillary adenopathy induced by COVID-19 vaccine: US follow-up evaluation
OBJECTIVES: This study was conducted in order to investigate COVID-19 vaccine influence on unilateral axillary lymph nodes, comparing nodal basal features with their characteristics after the first and second vaccination dose. METHODS: Ninety-one volunteer employees from our center who participated...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520081/ https://www.ncbi.nlm.nih.gov/pubmed/34655312 http://dx.doi.org/10.1007/s00330-021-08309-7 |
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author | Igual-Rouilleault, Alba Cristina Soriano, Ignacio Quan, Paola Leonor Fernández-Montero, Alejandro Elizalde, Arlette Pina, Luis |
author_facet | Igual-Rouilleault, Alba Cristina Soriano, Ignacio Quan, Paola Leonor Fernández-Montero, Alejandro Elizalde, Arlette Pina, Luis |
author_sort | Igual-Rouilleault, Alba Cristina |
collection | PubMed |
description | OBJECTIVES: This study was conducted in order to investigate COVID-19 vaccine influence on unilateral axillary lymph nodes, comparing nodal basal features with their characteristics after the first and second vaccination dose. METHODS: Ninety-one volunteer employees from our center who participated in the BNT162b2 (Pfizer-BioNTech) vaccination campaign were prospectively recruited. A total of three axillary ultrasound evaluations of the ipsilateral vaccinated arm were performed: before vaccination, the week after the first dose and the week after the second dose. The following findings were recorded: the total number of visible nodes, the maximum measurements of the diameter and cortex, Bedi’s classification, and color Doppler evaluation. The collected data were compared using paired-sample Student’s t-test for quantitative continuous variables and Wilcoxon rank-sum test for ordinal variables. Additional analyses were performed after classifying patients according to the previous history of COVID-19 disease. Differences among both groups were evaluated with the Mann–Whitney U test. Variables with a p value < 0.05 were considered statistically significant. RESULTS: Comparative analyses between the three US examinations showed a statistically significant augmentation of total visible nodes, maximum diameter, cortical thickness, grade of Bedi’s classification, and Doppler signal (p < 0.001). Analyses between patients with and without previous COVID-19 infection showed a higher lymph node response in naïve patients compared to those who were previously infected. CONCLUSIONS: According to our results, both doses of COVID-19 vaccine induced an increase of all axillary lymph node parameters with statistically significant differences, especially in coronavirus-naïve patients. KEY POINTS: • Pfizer COVID-19 vaccine induces a high incidence of ipsilateral axillary lymphadenopathy. • US scan identified an increase of all lymph nodes parameters, especially in coronavirus-naïve patients. |
format | Online Article Text |
id | pubmed-8520081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-85200812021-10-18 Unilateral axillary adenopathy induced by COVID-19 vaccine: US follow-up evaluation Igual-Rouilleault, Alba Cristina Soriano, Ignacio Quan, Paola Leonor Fernández-Montero, Alejandro Elizalde, Arlette Pina, Luis Eur Radiol Breast OBJECTIVES: This study was conducted in order to investigate COVID-19 vaccine influence on unilateral axillary lymph nodes, comparing nodal basal features with their characteristics after the first and second vaccination dose. METHODS: Ninety-one volunteer employees from our center who participated in the BNT162b2 (Pfizer-BioNTech) vaccination campaign were prospectively recruited. A total of three axillary ultrasound evaluations of the ipsilateral vaccinated arm were performed: before vaccination, the week after the first dose and the week after the second dose. The following findings were recorded: the total number of visible nodes, the maximum measurements of the diameter and cortex, Bedi’s classification, and color Doppler evaluation. The collected data were compared using paired-sample Student’s t-test for quantitative continuous variables and Wilcoxon rank-sum test for ordinal variables. Additional analyses were performed after classifying patients according to the previous history of COVID-19 disease. Differences among both groups were evaluated with the Mann–Whitney U test. Variables with a p value < 0.05 were considered statistically significant. RESULTS: Comparative analyses between the three US examinations showed a statistically significant augmentation of total visible nodes, maximum diameter, cortical thickness, grade of Bedi’s classification, and Doppler signal (p < 0.001). Analyses between patients with and without previous COVID-19 infection showed a higher lymph node response in naïve patients compared to those who were previously infected. CONCLUSIONS: According to our results, both doses of COVID-19 vaccine induced an increase of all axillary lymph node parameters with statistically significant differences, especially in coronavirus-naïve patients. KEY POINTS: • Pfizer COVID-19 vaccine induces a high incidence of ipsilateral axillary lymphadenopathy. • US scan identified an increase of all lymph nodes parameters, especially in coronavirus-naïve patients. Springer Berlin Heidelberg 2021-10-16 2022 /pmc/articles/PMC8520081/ /pubmed/34655312 http://dx.doi.org/10.1007/s00330-021-08309-7 Text en © The Author(s) 2021, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Breast Igual-Rouilleault, Alba Cristina Soriano, Ignacio Quan, Paola Leonor Fernández-Montero, Alejandro Elizalde, Arlette Pina, Luis Unilateral axillary adenopathy induced by COVID-19 vaccine: US follow-up evaluation |
title | Unilateral axillary adenopathy induced by COVID-19 vaccine: US follow-up evaluation |
title_full | Unilateral axillary adenopathy induced by COVID-19 vaccine: US follow-up evaluation |
title_fullStr | Unilateral axillary adenopathy induced by COVID-19 vaccine: US follow-up evaluation |
title_full_unstemmed | Unilateral axillary adenopathy induced by COVID-19 vaccine: US follow-up evaluation |
title_short | Unilateral axillary adenopathy induced by COVID-19 vaccine: US follow-up evaluation |
title_sort | unilateral axillary adenopathy induced by covid-19 vaccine: us follow-up evaluation |
topic | Breast |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520081/ https://www.ncbi.nlm.nih.gov/pubmed/34655312 http://dx.doi.org/10.1007/s00330-021-08309-7 |
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