Cargando…

Pediatric Chronic Critical Illness: Protocol for a Scoping Review

BACKGROUND: Improvements in the delivery of intensive care have increased survival among even the most critically ill children, thereby leading to a growing number of children with chronic complex medical conditions in the pediatric intensive care unit (PICU). Some of these children are at a signifi...

Descripción completa

Detalles Bibliográficos
Autores principales: Zorko, David, McNally, James Dayre, Rochwerg, Bram, Pinto, Neethi, Couban, Rachel, O’Hearn, Katie, Choong, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JMIR Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520133/
https://www.ncbi.nlm.nih.gov/pubmed/34596576
http://dx.doi.org/10.2196/30582
_version_ 1784584603020820480
author Zorko, David
McNally, James Dayre
Rochwerg, Bram
Pinto, Neethi
Couban, Rachel
O’Hearn, Katie
Choong, Karen
author_facet Zorko, David
McNally, James Dayre
Rochwerg, Bram
Pinto, Neethi
Couban, Rachel
O’Hearn, Katie
Choong, Karen
author_sort Zorko, David
collection PubMed
description BACKGROUND: Improvements in the delivery of intensive care have increased survival among even the most critically ill children, thereby leading to a growing number of children with chronic complex medical conditions in the pediatric intensive care unit (PICU). Some of these children are at a significant risk of recurrent and prolonged critical illness, with higher morbidity and mortality, making them a unique population described as having chronic critical illness (CCI). To date, pediatric CCI has been understudied and lacks an accepted consensus case definition. OBJECTIVE: This study aims to describe the protocol and methodology used to perform a scoping review that will describe how pediatric CCI has been defined in the literature, including the concept of prolonged PICU admission and the methodologies used to develop any existing definitions. It also aims to describe patient characteristics and outcomes evaluated in the included studies. METHODS: We will search four electronic databases for studies that evaluated children admitted to any PICU identified with CCI. We will also search for studies describing prolonged PICU admission, as this concept is related to pediatric CCI. Furthermore, we will develop a hybrid crowdsourcing and machine learning (ML) methodology to complete citation screening. Screening and data abstraction will be performed by 2 reviewers independently and in duplicate. Data abstraction will include the details of population definitions, demographic and clinical characteristics of children with CCI, and evaluated outcomes. RESULTS: The database search, crowd reviewer recruitment, and ML algorithm development began in March 2021. Citation screening and data abstraction were completed in April 2021. Final data verification is ongoing, with analysis and results anticipated to be completed by fall 2021. CONCLUSIONS: This scoping review will describe the existing or suggested definitions of pediatric CCI and important demographic and clinical characteristics of patients to whom these definitions have been applied. This review’s results will help inform the development of a consensus case definition for pediatric CCI and set a priority agenda for future research. We will use and demonstrate the validity of crowdsourcing and ML methodologies for improving the efficiency of large scoping reviews. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/30582
format Online
Article
Text
id pubmed-8520133
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher JMIR Publications
record_format MEDLINE/PubMed
spelling pubmed-85201332021-11-09 Pediatric Chronic Critical Illness: Protocol for a Scoping Review Zorko, David McNally, James Dayre Rochwerg, Bram Pinto, Neethi Couban, Rachel O’Hearn, Katie Choong, Karen JMIR Res Protoc Protocol BACKGROUND: Improvements in the delivery of intensive care have increased survival among even the most critically ill children, thereby leading to a growing number of children with chronic complex medical conditions in the pediatric intensive care unit (PICU). Some of these children are at a significant risk of recurrent and prolonged critical illness, with higher morbidity and mortality, making them a unique population described as having chronic critical illness (CCI). To date, pediatric CCI has been understudied and lacks an accepted consensus case definition. OBJECTIVE: This study aims to describe the protocol and methodology used to perform a scoping review that will describe how pediatric CCI has been defined in the literature, including the concept of prolonged PICU admission and the methodologies used to develop any existing definitions. It also aims to describe patient characteristics and outcomes evaluated in the included studies. METHODS: We will search four electronic databases for studies that evaluated children admitted to any PICU identified with CCI. We will also search for studies describing prolonged PICU admission, as this concept is related to pediatric CCI. Furthermore, we will develop a hybrid crowdsourcing and machine learning (ML) methodology to complete citation screening. Screening and data abstraction will be performed by 2 reviewers independently and in duplicate. Data abstraction will include the details of population definitions, demographic and clinical characteristics of children with CCI, and evaluated outcomes. RESULTS: The database search, crowd reviewer recruitment, and ML algorithm development began in March 2021. Citation screening and data abstraction were completed in April 2021. Final data verification is ongoing, with analysis and results anticipated to be completed by fall 2021. CONCLUSIONS: This scoping review will describe the existing or suggested definitions of pediatric CCI and important demographic and clinical characteristics of patients to whom these definitions have been applied. This review’s results will help inform the development of a consensus case definition for pediatric CCI and set a priority agenda for future research. We will use and demonstrate the validity of crowdsourcing and ML methodologies for improving the efficiency of large scoping reviews. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/30582 JMIR Publications 2021-10-01 /pmc/articles/PMC8520133/ /pubmed/34596576 http://dx.doi.org/10.2196/30582 Text en ©David Zorko, James Dayre McNally, Bram Rochwerg, Neethi Pinto, Rachel Couban, Katie O’Hearn, Karen Choong. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 01.10.2021. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on https://www.researchprotocols.org, as well as this copyright and license information must be included.
spellingShingle Protocol
Zorko, David
McNally, James Dayre
Rochwerg, Bram
Pinto, Neethi
Couban, Rachel
O’Hearn, Katie
Choong, Karen
Pediatric Chronic Critical Illness: Protocol for a Scoping Review
title Pediatric Chronic Critical Illness: Protocol for a Scoping Review
title_full Pediatric Chronic Critical Illness: Protocol for a Scoping Review
title_fullStr Pediatric Chronic Critical Illness: Protocol for a Scoping Review
title_full_unstemmed Pediatric Chronic Critical Illness: Protocol for a Scoping Review
title_short Pediatric Chronic Critical Illness: Protocol for a Scoping Review
title_sort pediatric chronic critical illness: protocol for a scoping review
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520133/
https://www.ncbi.nlm.nih.gov/pubmed/34596576
http://dx.doi.org/10.2196/30582
work_keys_str_mv AT zorkodavid pediatricchroniccriticalillnessprotocolforascopingreview
AT mcnallyjamesdayre pediatricchroniccriticalillnessprotocolforascopingreview
AT rochwergbram pediatricchroniccriticalillnessprotocolforascopingreview
AT pintoneethi pediatricchroniccriticalillnessprotocolforascopingreview
AT coubanrachel pediatricchroniccriticalillnessprotocolforascopingreview
AT ohearnkatie pediatricchroniccriticalillnessprotocolforascopingreview
AT choongkaren pediatricchroniccriticalillnessprotocolforascopingreview