Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models

BACKGROUND: Patients with ovarian cancer often present at advanced stage and, following initial treatment success, develop recurrent drug-resistant disease. PARP inhibitors (PARPi) are yielding unprecedented survival benefits for women with BRCA-deficient disease. However, options remain limited for...

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Detalles Bibliográficos
Autores principales: Coulson-Gilmer, Camilla, Morgan, Robert D., Nelson, Louisa, Barnes, Bethany M., Tighe, Anthony, Wardenaar, René, Spierings, Diana C. J., Schlecht, Helene, Burghel, George J., Foijer, Floris, Desai, Sudha, McGrail, Joanne C., Taylor, Stephen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520217/
https://www.ncbi.nlm.nih.gov/pubmed/34656146
http://dx.doi.org/10.1186/s13046-021-02124-0

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