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Surgical removal of a telemetry system in a cynomolgus monkey (Macaca fascicularis): a 12-month observation study

BACKGROUND: Telemetry is a wireless implanted device that measures biological signals in conscious animals and usually requires surgery for its removal when the study is finished. After removing the device, the animals are either used for other studies or euthanatized. CASE PRESENTATION: Herein, we...

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Autores principales: Cho, Doo-Wan, Han, Hyoung-Yun, Yang, Mi-Jin, Woo, Dong Ho, Han, Su-Cheol, Yang, Young-Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520245/
https://www.ncbi.nlm.nih.gov/pubmed/34656182
http://dx.doi.org/10.1186/s42826-021-00106-z
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author Cho, Doo-Wan
Han, Hyoung-Yun
Yang, Mi-Jin
Woo, Dong Ho
Han, Su-Cheol
Yang, Young-Su
author_facet Cho, Doo-Wan
Han, Hyoung-Yun
Yang, Mi-Jin
Woo, Dong Ho
Han, Su-Cheol
Yang, Young-Su
author_sort Cho, Doo-Wan
collection PubMed
description BACKGROUND: Telemetry is a wireless implanted device that measures biological signals in conscious animals and usually requires surgery for its removal when the study is finished. After removing the device, the animals are either used for other studies or euthanatized. CASE PRESENTATION: Herein, we report the case of a living cynomolgus monkey (Macaca fascicularis) that was used for the entire experimental period, instead of euthanasia, after surgical removal of an implanted telemetry system. Radiography was used to determine the status of the implanted telemetry, following which, a repair surgery was performed for removing the system; clinical signs were used to preserve the life of the cynomolgus monkey. Postoperative clinical signs, food consumption, hematology, and serum biochemistry were examined during the 12-month observational period. No abnormal readings or conditions were observed in the subject after implant removal. CONCLUSIONS: This study may be a useful case report for living cynomolgus monkeys in telemetry implantations used throughout the study period. We suggest minimizing the suffering and improving the welfare of these animals. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s42826-021-00106-z.
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spelling pubmed-85202452021-10-20 Surgical removal of a telemetry system in a cynomolgus monkey (Macaca fascicularis): a 12-month observation study Cho, Doo-Wan Han, Hyoung-Yun Yang, Mi-Jin Woo, Dong Ho Han, Su-Cheol Yang, Young-Su Lab Anim Res Case Report BACKGROUND: Telemetry is a wireless implanted device that measures biological signals in conscious animals and usually requires surgery for its removal when the study is finished. After removing the device, the animals are either used for other studies or euthanatized. CASE PRESENTATION: Herein, we report the case of a living cynomolgus monkey (Macaca fascicularis) that was used for the entire experimental period, instead of euthanasia, after surgical removal of an implanted telemetry system. Radiography was used to determine the status of the implanted telemetry, following which, a repair surgery was performed for removing the system; clinical signs were used to preserve the life of the cynomolgus monkey. Postoperative clinical signs, food consumption, hematology, and serum biochemistry were examined during the 12-month observational period. No abnormal readings or conditions were observed in the subject after implant removal. CONCLUSIONS: This study may be a useful case report for living cynomolgus monkeys in telemetry implantations used throughout the study period. We suggest minimizing the suffering and improving the welfare of these animals. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s42826-021-00106-z. BioMed Central 2021-10-16 /pmc/articles/PMC8520245/ /pubmed/34656182 http://dx.doi.org/10.1186/s42826-021-00106-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Cho, Doo-Wan
Han, Hyoung-Yun
Yang, Mi-Jin
Woo, Dong Ho
Han, Su-Cheol
Yang, Young-Su
Surgical removal of a telemetry system in a cynomolgus monkey (Macaca fascicularis): a 12-month observation study
title Surgical removal of a telemetry system in a cynomolgus monkey (Macaca fascicularis): a 12-month observation study
title_full Surgical removal of a telemetry system in a cynomolgus monkey (Macaca fascicularis): a 12-month observation study
title_fullStr Surgical removal of a telemetry system in a cynomolgus monkey (Macaca fascicularis): a 12-month observation study
title_full_unstemmed Surgical removal of a telemetry system in a cynomolgus monkey (Macaca fascicularis): a 12-month observation study
title_short Surgical removal of a telemetry system in a cynomolgus monkey (Macaca fascicularis): a 12-month observation study
title_sort surgical removal of a telemetry system in a cynomolgus monkey (macaca fascicularis): a 12-month observation study
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520245/
https://www.ncbi.nlm.nih.gov/pubmed/34656182
http://dx.doi.org/10.1186/s42826-021-00106-z
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