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Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda
Autism spectrum disorder (ASD) impacts an individual’s ability to socialize, communicate, and interact with, and adapt to, the environment. Over the last two decades, research has focused on early identification of ASD with significant progress being made in understanding the early behavioral and bi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520312/ https://www.ncbi.nlm.nih.gov/pubmed/34654371 http://dx.doi.org/10.1186/s11689-021-09393-y |
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author | Grzadzinski, Rebecca Amso, Dima Landa, Rebecca Watson, Linda Guralnick, Michael Zwaigenbaum, Lonnie Deák, Gedeon Estes, Annette Brian, Jessica Bath, Kevin Elison, Jed Abbeduto, Leonard Wolff, Jason Piven, Joseph |
author_facet | Grzadzinski, Rebecca Amso, Dima Landa, Rebecca Watson, Linda Guralnick, Michael Zwaigenbaum, Lonnie Deák, Gedeon Estes, Annette Brian, Jessica Bath, Kevin Elison, Jed Abbeduto, Leonard Wolff, Jason Piven, Joseph |
author_sort | Grzadzinski, Rebecca |
collection | PubMed |
description | Autism spectrum disorder (ASD) impacts an individual’s ability to socialize, communicate, and interact with, and adapt to, the environment. Over the last two decades, research has focused on early identification of ASD with significant progress being made in understanding the early behavioral and biological markers that precede a diagnosis, providing a catalyst for pre-symptomatic identification and intervention. Evidence from preclinical trials suggest that intervention prior to the onset of ASD symptoms may yield more improved developmental outcomes, and clinical studies suggest that the earlier intervention is administered, the better the outcomes. This article brings together a multidisciplinary group of experts to develop a conceptual framework for behavioral intervention, during the pre-symptomatic period prior to the consolidation of symptoms into diagnosis, in infants at very-high-likelihood for developing ASD (VHL-ASD). The overarching goals of this paper are to promote the development of new intervention approaches, empirical research, and policy efforts aimed at VHL-ASD infants during the pre-symptomatic period (i.e., prior to the consolidation of the defining features of ASD). |
format | Online Article Text |
id | pubmed-8520312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85203122021-10-20 Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda Grzadzinski, Rebecca Amso, Dima Landa, Rebecca Watson, Linda Guralnick, Michael Zwaigenbaum, Lonnie Deák, Gedeon Estes, Annette Brian, Jessica Bath, Kevin Elison, Jed Abbeduto, Leonard Wolff, Jason Piven, Joseph J Neurodev Disord Review Autism spectrum disorder (ASD) impacts an individual’s ability to socialize, communicate, and interact with, and adapt to, the environment. Over the last two decades, research has focused on early identification of ASD with significant progress being made in understanding the early behavioral and biological markers that precede a diagnosis, providing a catalyst for pre-symptomatic identification and intervention. Evidence from preclinical trials suggest that intervention prior to the onset of ASD symptoms may yield more improved developmental outcomes, and clinical studies suggest that the earlier intervention is administered, the better the outcomes. This article brings together a multidisciplinary group of experts to develop a conceptual framework for behavioral intervention, during the pre-symptomatic period prior to the consolidation of symptoms into diagnosis, in infants at very-high-likelihood for developing ASD (VHL-ASD). The overarching goals of this paper are to promote the development of new intervention approaches, empirical research, and policy efforts aimed at VHL-ASD infants during the pre-symptomatic period (i.e., prior to the consolidation of the defining features of ASD). BioMed Central 2021-10-15 /pmc/articles/PMC8520312/ /pubmed/34654371 http://dx.doi.org/10.1186/s11689-021-09393-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Grzadzinski, Rebecca Amso, Dima Landa, Rebecca Watson, Linda Guralnick, Michael Zwaigenbaum, Lonnie Deák, Gedeon Estes, Annette Brian, Jessica Bath, Kevin Elison, Jed Abbeduto, Leonard Wolff, Jason Piven, Joseph Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda |
title | Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda |
title_full | Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda |
title_fullStr | Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda |
title_full_unstemmed | Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda |
title_short | Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda |
title_sort | pre-symptomatic intervention for autism spectrum disorder (asd): defining a research agenda |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520312/ https://www.ncbi.nlm.nih.gov/pubmed/34654371 http://dx.doi.org/10.1186/s11689-021-09393-y |
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