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The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: a prospective study in Japan

The aim of this study was to evaluate the antibody reaction after administration of the BNT162b2 vaccine, and to reveal the factors that affect antibody production. This prospective study was carried out in the Association of EISEIKAI Medical and Healthcare Corporation Minamitama Hospital, in Tokyo,...

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Autores principales: Mitsunaga, Toshiya, Ohtaki, Yuhei, Seki, Yutaka, Yoshioka, Masakata, Mori, Hiroshi, Suzuka, Midori, Mashiko, Syunsuke, Takeda, Satoshi, Mashiko, Kunihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520395/
https://www.ncbi.nlm.nih.gov/pubmed/34721989
http://dx.doi.org/10.7717/peerj.12316
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author Mitsunaga, Toshiya
Ohtaki, Yuhei
Seki, Yutaka
Yoshioka, Masakata
Mori, Hiroshi
Suzuka, Midori
Mashiko, Syunsuke
Takeda, Satoshi
Mashiko, Kunihiro
author_facet Mitsunaga, Toshiya
Ohtaki, Yuhei
Seki, Yutaka
Yoshioka, Masakata
Mori, Hiroshi
Suzuka, Midori
Mashiko, Syunsuke
Takeda, Satoshi
Mashiko, Kunihiro
author_sort Mitsunaga, Toshiya
collection PubMed
description The aim of this study was to evaluate the antibody reaction after administration of the BNT162b2 vaccine, and to reveal the factors that affect antibody production. This prospective study was carried out in the Association of EISEIKAI Medical and Healthcare Corporation Minamitama Hospital, in Tokyo, Japan, from April 15, 2021 to June 09, 2021. All our hospital’s workers who were administered the BNT162b2 vaccine as part of a routine program were included in this study. We calculated the anti-SARS-CoV-2 spike-specific antibody titter (1) before vaccination, (2) 7 to 20 days after the first vaccination, and (3) A total of 7 to 20 days after the second vaccination. The low-antibody titer group (LABG) was defined as the group having less than 25 percentiles of antibody titer. Univariate and Multivariate logistic regression analysis were performed to ascertain the effects of factors on the likelihood of LABG. A total of 374 participants were eventually included in our study, and they were divided into 94 LABG and 280 non-LABG. All samples showed significant antibody elevation in the second antibody test, with a mean value of 3,476 U/mL. When comparing the LABG and non-LABG groups, the median age, blood sugar, and HbA1c were significantly higher in the LABG group. The rates of participants with low BMI (<18.5) and high BMI (>30) were significantly higher in the LABG group. The proportion of chronic lung disease, hypertension, diabetes, dyslipidemia, autoimmune disease, and cancer were significantly higher in the LABG group. Although there was no significant difference confirmed with respect to the exercise hours per day, the proportion of participants that did not perform outdoor exercises was significantly higher in the LABG group. The time interval between the second vaccination and the second antibody test, and between the first and the second vaccination was significantly longer in the non-LABG group. In the multivariate logistic regression analysis, older than 60 years, the past history of hypertension, HbA1c higher than 6.5%, and lack of outdoor exercises were significant suppressors of antibody responses, whereas the length of days from the first to the second vaccination longer than 25 days promoted a significant antibody response. Again, our single-center study demonstrates that older than 60 years, hypertension, HbA1c higher than 6.5%, and lack of outdoor exercises were significant suppressors of antibody responses, whereas the length of days from the first to the second vaccination longer than 25 days promoted a significant antibody response. Evidence from multi-center studies is needed to develop further vaccination strategies.
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spelling pubmed-85203952021-10-28 The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: a prospective study in Japan Mitsunaga, Toshiya Ohtaki, Yuhei Seki, Yutaka Yoshioka, Masakata Mori, Hiroshi Suzuka, Midori Mashiko, Syunsuke Takeda, Satoshi Mashiko, Kunihiro PeerJ Global Health The aim of this study was to evaluate the antibody reaction after administration of the BNT162b2 vaccine, and to reveal the factors that affect antibody production. This prospective study was carried out in the Association of EISEIKAI Medical and Healthcare Corporation Minamitama Hospital, in Tokyo, Japan, from April 15, 2021 to June 09, 2021. All our hospital’s workers who were administered the BNT162b2 vaccine as part of a routine program were included in this study. We calculated the anti-SARS-CoV-2 spike-specific antibody titter (1) before vaccination, (2) 7 to 20 days after the first vaccination, and (3) A total of 7 to 20 days after the second vaccination. The low-antibody titer group (LABG) was defined as the group having less than 25 percentiles of antibody titer. Univariate and Multivariate logistic regression analysis were performed to ascertain the effects of factors on the likelihood of LABG. A total of 374 participants were eventually included in our study, and they were divided into 94 LABG and 280 non-LABG. All samples showed significant antibody elevation in the second antibody test, with a mean value of 3,476 U/mL. When comparing the LABG and non-LABG groups, the median age, blood sugar, and HbA1c were significantly higher in the LABG group. The rates of participants with low BMI (<18.5) and high BMI (>30) were significantly higher in the LABG group. The proportion of chronic lung disease, hypertension, diabetes, dyslipidemia, autoimmune disease, and cancer were significantly higher in the LABG group. Although there was no significant difference confirmed with respect to the exercise hours per day, the proportion of participants that did not perform outdoor exercises was significantly higher in the LABG group. The time interval between the second vaccination and the second antibody test, and between the first and the second vaccination was significantly longer in the non-LABG group. In the multivariate logistic regression analysis, older than 60 years, the past history of hypertension, HbA1c higher than 6.5%, and lack of outdoor exercises were significant suppressors of antibody responses, whereas the length of days from the first to the second vaccination longer than 25 days promoted a significant antibody response. Again, our single-center study demonstrates that older than 60 years, hypertension, HbA1c higher than 6.5%, and lack of outdoor exercises were significant suppressors of antibody responses, whereas the length of days from the first to the second vaccination longer than 25 days promoted a significant antibody response. Evidence from multi-center studies is needed to develop further vaccination strategies. PeerJ Inc. 2021-10-13 /pmc/articles/PMC8520395/ /pubmed/34721989 http://dx.doi.org/10.7717/peerj.12316 Text en © 2021 Mitsunaga et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Global Health
Mitsunaga, Toshiya
Ohtaki, Yuhei
Seki, Yutaka
Yoshioka, Masakata
Mori, Hiroshi
Suzuka, Midori
Mashiko, Syunsuke
Takeda, Satoshi
Mashiko, Kunihiro
The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: a prospective study in Japan
title The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: a prospective study in Japan
title_full The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: a prospective study in Japan
title_fullStr The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: a prospective study in Japan
title_full_unstemmed The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: a prospective study in Japan
title_short The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: a prospective study in Japan
title_sort evaluation of factors affecting antibody response after administration of the bnt162b2 vaccine: a prospective study in japan
topic Global Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520395/
https://www.ncbi.nlm.nih.gov/pubmed/34721989
http://dx.doi.org/10.7717/peerj.12316
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