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Regulation of autophagy by miRNAs in human diseases
Autophagy is a homeostatic process designed to eliminate dysfunctional and aging organelles and misfolded proteins through a well-concerted pathway, starting with forming a double-membrane vesicle and culminating in the lysosomal degradation of the cargo enclosed inside the mature vesicle. As a vita...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer India
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520464/ https://www.ncbi.nlm.nih.gov/pubmed/34690368 http://dx.doi.org/10.1007/s13237-021-00378-9 |
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author | Roy, Sounak Ghosh |
author_facet | Roy, Sounak Ghosh |
author_sort | Roy, Sounak Ghosh |
collection | PubMed |
description | Autophagy is a homeostatic process designed to eliminate dysfunctional and aging organelles and misfolded proteins through a well-concerted pathway, starting with forming a double-membrane vesicle and culminating in the lysosomal degradation of the cargo enclosed inside the mature vesicle. As a vital sentry of cellular health, autophagy is regulated in every human disease condition and is an essential target for non-coding RNAs like microRNAs (miRNAs). miRNAs are short oligonucleotides that specifically bind to the 3'-untranslated region (UTR) of target mRNAs, thus leading to mRNA silencing, degradation, or translation blockage. This review summarizes the recent findings regarding the regulation of autophagy and autophagy-related genes by different miRNAs in various pathological conditions, including cancer, kidney and liver disorders, neurodegeneration, cardiovascular disorders, infectious diseases, aging-related conditions, and inflammation-related diseases. As miRNAs are being identified as prime regulators of autophagy in human disease, pharmacological molecules and traditional medicines targeting these miRNAs are also being tested in disease models, thus initiating a new series of therapeutic interventions targeting autophagy. |
format | Online Article Text |
id | pubmed-8520464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer India |
record_format | MEDLINE/PubMed |
spelling | pubmed-85204642021-10-18 Regulation of autophagy by miRNAs in human diseases Roy, Sounak Ghosh Nucleus (Calcutta) Review Article Autophagy is a homeostatic process designed to eliminate dysfunctional and aging organelles and misfolded proteins through a well-concerted pathway, starting with forming a double-membrane vesicle and culminating in the lysosomal degradation of the cargo enclosed inside the mature vesicle. As a vital sentry of cellular health, autophagy is regulated in every human disease condition and is an essential target for non-coding RNAs like microRNAs (miRNAs). miRNAs are short oligonucleotides that specifically bind to the 3'-untranslated region (UTR) of target mRNAs, thus leading to mRNA silencing, degradation, or translation blockage. This review summarizes the recent findings regarding the regulation of autophagy and autophagy-related genes by different miRNAs in various pathological conditions, including cancer, kidney and liver disorders, neurodegeneration, cardiovascular disorders, infectious diseases, aging-related conditions, and inflammation-related diseases. As miRNAs are being identified as prime regulators of autophagy in human disease, pharmacological molecules and traditional medicines targeting these miRNAs are also being tested in disease models, thus initiating a new series of therapeutic interventions targeting autophagy. Springer India 2021-10-16 2021 /pmc/articles/PMC8520464/ /pubmed/34690368 http://dx.doi.org/10.1007/s13237-021-00378-9 Text en © Archana Sharma Foundation of Calcutta 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Roy, Sounak Ghosh Regulation of autophagy by miRNAs in human diseases |
title | Regulation of autophagy by miRNAs in human diseases |
title_full | Regulation of autophagy by miRNAs in human diseases |
title_fullStr | Regulation of autophagy by miRNAs in human diseases |
title_full_unstemmed | Regulation of autophagy by miRNAs in human diseases |
title_short | Regulation of autophagy by miRNAs in human diseases |
title_sort | regulation of autophagy by mirnas in human diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520464/ https://www.ncbi.nlm.nih.gov/pubmed/34690368 http://dx.doi.org/10.1007/s13237-021-00378-9 |
work_keys_str_mv | AT roysounakghosh regulationofautophagybymirnasinhumandiseases |