Correlation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome

Good syndrome is a rare condition characterized by the presence of thymoma in combination with adult-onset hypogammaglobulinemia. Immunological features of Good syndrome include various immunodeficiencies accompanied with hypogammaglobulinemia. In patients with thymoma, paraneoplastic syndromes incl...

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Autores principales: Kitano, Haruka, Yamaguchi, Fumihiro, Atarashi, Kenji, Hiraiwa, Mina, Shiratori, Yo, Onozaki, Shota, Shikama, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520479/
https://www.ncbi.nlm.nih.gov/pubmed/34675549
http://dx.doi.org/10.2147/OTT.S326193
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author Kitano, Haruka
Yamaguchi, Fumihiro
Atarashi, Kenji
Hiraiwa, Mina
Shiratori, Yo
Onozaki, Shota
Shikama, Yusuke
author_facet Kitano, Haruka
Yamaguchi, Fumihiro
Atarashi, Kenji
Hiraiwa, Mina
Shiratori, Yo
Onozaki, Shota
Shikama, Yusuke
author_sort Kitano, Haruka
collection PubMed
description Good syndrome is a rare condition characterized by the presence of thymoma in combination with adult-onset hypogammaglobulinemia. Immunological features of Good syndrome include various immunodeficiencies accompanied with hypogammaglobulinemia. In patients with thymoma, paraneoplastic syndromes including hypogammaglobulinemia worsen the prognosis. We herein describe a patient with advanced-stage type A thymoma who was effectively treated with chemotherapy and exhibited a parallel decrease in the serum level of soluble interleukin-2 receptor (sIL-2R), which depends on cellular immunity. The present case suggests the efficacy of sIL-2R as a potential prognostic biomarker in a subset of patients with Good syndrome.
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spelling pubmed-85204792021-10-20 Correlation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome Kitano, Haruka Yamaguchi, Fumihiro Atarashi, Kenji Hiraiwa, Mina Shiratori, Yo Onozaki, Shota Shikama, Yusuke Onco Targets Ther Case Report Good syndrome is a rare condition characterized by the presence of thymoma in combination with adult-onset hypogammaglobulinemia. Immunological features of Good syndrome include various immunodeficiencies accompanied with hypogammaglobulinemia. In patients with thymoma, paraneoplastic syndromes including hypogammaglobulinemia worsen the prognosis. We herein describe a patient with advanced-stage type A thymoma who was effectively treated with chemotherapy and exhibited a parallel decrease in the serum level of soluble interleukin-2 receptor (sIL-2R), which depends on cellular immunity. The present case suggests the efficacy of sIL-2R as a potential prognostic biomarker in a subset of patients with Good syndrome. Dove 2021-10-12 /pmc/articles/PMC8520479/ /pubmed/34675549 http://dx.doi.org/10.2147/OTT.S326193 Text en © 2021 Kitano et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Kitano, Haruka
Yamaguchi, Fumihiro
Atarashi, Kenji
Hiraiwa, Mina
Shiratori, Yo
Onozaki, Shota
Shikama, Yusuke
Correlation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome
title Correlation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome
title_full Correlation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome
title_fullStr Correlation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome
title_full_unstemmed Correlation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome
title_short Correlation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome
title_sort correlation between thymoma and soluble interleukin-2 receptor expression in a patient with good syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520479/
https://www.ncbi.nlm.nih.gov/pubmed/34675549
http://dx.doi.org/10.2147/OTT.S326193
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