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Lupus Enteritis: An Uncommon Presentation of Lupus Flare
Gastrointestinal (GI) symptoms are common in systemic lupus erythematosus (SLE) but are usually attributable to medication side effects, infections, or other underlying conditions. In rare cases, they are caused by the autoimmune process itself. In this report, we present two cases of lupus enteriti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520498/ https://www.ncbi.nlm.nih.gov/pubmed/34671520 http://dx.doi.org/10.7759/cureus.18030 |
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author | Potera, Joanna Palomera Tejeda, Emmanuel Arora, Shilpa Manadan, Augustine M |
author_facet | Potera, Joanna Palomera Tejeda, Emmanuel Arora, Shilpa Manadan, Augustine M |
author_sort | Potera, Joanna |
collection | PubMed |
description | Gastrointestinal (GI) symptoms are common in systemic lupus erythematosus (SLE) but are usually attributable to medication side effects, infections, or other underlying conditions. In rare cases, they are caused by the autoimmune process itself. In this report, we present two cases of lupus enteritis as the sole manifestation of lupus flare. We also provide a comprehensive review of available literature on this topic with a specific focus on clinical symptoms, complications, laboratory findings, histology, imaging findings, and therapies. Lupus enteritis is an uncommon manifestation of SLE. CT scan of the abdomen is the diagnostic modality of choice. The three major CT findings are target sign, comb sign, and increased mesenteric fat attenuation. Ascites is also commonly present. Corticosteroids and second-line immunosuppressants have been successfully employed in the treatment of lupus enteritis. Our cases highlight this unusual manifestation as the only symptom of active SLE. A high index of suspicion should be maintained when evaluating SLE patients presenting with GI symptoms to prevent diagnosis and treatment delays that could lead to serious complications such as bowel necrosis, perforation, and even death. |
format | Online Article Text |
id | pubmed-8520498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-85204982021-10-19 Lupus Enteritis: An Uncommon Presentation of Lupus Flare Potera, Joanna Palomera Tejeda, Emmanuel Arora, Shilpa Manadan, Augustine M Cureus Gastroenterology Gastrointestinal (GI) symptoms are common in systemic lupus erythematosus (SLE) but are usually attributable to medication side effects, infections, or other underlying conditions. In rare cases, they are caused by the autoimmune process itself. In this report, we present two cases of lupus enteritis as the sole manifestation of lupus flare. We also provide a comprehensive review of available literature on this topic with a specific focus on clinical symptoms, complications, laboratory findings, histology, imaging findings, and therapies. Lupus enteritis is an uncommon manifestation of SLE. CT scan of the abdomen is the diagnostic modality of choice. The three major CT findings are target sign, comb sign, and increased mesenteric fat attenuation. Ascites is also commonly present. Corticosteroids and second-line immunosuppressants have been successfully employed in the treatment of lupus enteritis. Our cases highlight this unusual manifestation as the only symptom of active SLE. A high index of suspicion should be maintained when evaluating SLE patients presenting with GI symptoms to prevent diagnosis and treatment delays that could lead to serious complications such as bowel necrosis, perforation, and even death. Cureus 2021-09-16 /pmc/articles/PMC8520498/ /pubmed/34671520 http://dx.doi.org/10.7759/cureus.18030 Text en Copyright © 2021, Potera et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Gastroenterology Potera, Joanna Palomera Tejeda, Emmanuel Arora, Shilpa Manadan, Augustine M Lupus Enteritis: An Uncommon Presentation of Lupus Flare |
title | Lupus Enteritis: An Uncommon Presentation of Lupus Flare |
title_full | Lupus Enteritis: An Uncommon Presentation of Lupus Flare |
title_fullStr | Lupus Enteritis: An Uncommon Presentation of Lupus Flare |
title_full_unstemmed | Lupus Enteritis: An Uncommon Presentation of Lupus Flare |
title_short | Lupus Enteritis: An Uncommon Presentation of Lupus Flare |
title_sort | lupus enteritis: an uncommon presentation of lupus flare |
topic | Gastroenterology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520498/ https://www.ncbi.nlm.nih.gov/pubmed/34671520 http://dx.doi.org/10.7759/cureus.18030 |
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