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The impact of varicella vaccination on paediatric herpes zoster epidemiology: a Canadian population-based retrospective cohort study

The impact of universal varicella vaccination on herpes zoster (HZ) risk in unvaccinated and vaccinated children, and its long-term influence on HZ epidemiology, remains unknown. We conducted a retrospective cohort study using population-based administrative health data for children born between 199...

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Autores principales: Rafferty, Ellen, Reifferscheid, Laura, Russell, Margaret L., Booth, Stephanie, Svenson, Lawrence W., MacDonald, Shannon E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520524/
https://www.ncbi.nlm.nih.gov/pubmed/34175998
http://dx.doi.org/10.1007/s10096-021-04298-z
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author Rafferty, Ellen
Reifferscheid, Laura
Russell, Margaret L.
Booth, Stephanie
Svenson, Lawrence W.
MacDonald, Shannon E.
author_facet Rafferty, Ellen
Reifferscheid, Laura
Russell, Margaret L.
Booth, Stephanie
Svenson, Lawrence W.
MacDonald, Shannon E.
author_sort Rafferty, Ellen
collection PubMed
description The impact of universal varicella vaccination on herpes zoster (HZ) risk in unvaccinated and vaccinated children, and its long-term influence on HZ epidemiology, remains unknown. We conducted a retrospective cohort study using population-based administrative health data for children born between 1993 and 2018 (n = 924,124). We calculated age-specific cumulative HZ incidence rates by vaccination status for cohorts born before (1993–1999) and after (2000–2018) programme implementation; results were used to calculate relative risk of HZ by age group, vaccination status and vaccine availability period. Annual HZ incidence rates were calculated for 1993–2018. HZ risk was higher among unvaccinated children compared to vaccinated children across age groups; 64% higher before universal vaccination (RR: 0.36, 95% CI: 0.33, 0.39), and 32% higher after universal vaccination (RR: 0.68, 95% CI: 0.64, 0.73). Among unvaccinated children, HZ risk was 60% lower after vaccine programme implementation (RR: 0.40, 95% CI: 0.38, 0.43). Two-dose receipt corresponded with a 41% lower risk of HZ compared to one-dose receipt (RR: 0.59, 95% CI: 0.53, 0.65). Crude annual HZ incidence rates declined 64% after programme implementation, with decreases observed across age groups. Universal varicella vaccination programme implementation corresponds to decreased paediatric HZ incidence across age groups, in both vaccinated and unvaccinated individuals. Results from this study can be used to help inform varicella vaccination programme decision-making in other countries.
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spelling pubmed-85205242021-10-29 The impact of varicella vaccination on paediatric herpes zoster epidemiology: a Canadian population-based retrospective cohort study Rafferty, Ellen Reifferscheid, Laura Russell, Margaret L. Booth, Stephanie Svenson, Lawrence W. MacDonald, Shannon E. Eur J Clin Microbiol Infect Dis Original Article The impact of universal varicella vaccination on herpes zoster (HZ) risk in unvaccinated and vaccinated children, and its long-term influence on HZ epidemiology, remains unknown. We conducted a retrospective cohort study using population-based administrative health data for children born between 1993 and 2018 (n = 924,124). We calculated age-specific cumulative HZ incidence rates by vaccination status for cohorts born before (1993–1999) and after (2000–2018) programme implementation; results were used to calculate relative risk of HZ by age group, vaccination status and vaccine availability period. Annual HZ incidence rates were calculated for 1993–2018. HZ risk was higher among unvaccinated children compared to vaccinated children across age groups; 64% higher before universal vaccination (RR: 0.36, 95% CI: 0.33, 0.39), and 32% higher after universal vaccination (RR: 0.68, 95% CI: 0.64, 0.73). Among unvaccinated children, HZ risk was 60% lower after vaccine programme implementation (RR: 0.40, 95% CI: 0.38, 0.43). Two-dose receipt corresponded with a 41% lower risk of HZ compared to one-dose receipt (RR: 0.59, 95% CI: 0.53, 0.65). Crude annual HZ incidence rates declined 64% after programme implementation, with decreases observed across age groups. Universal varicella vaccination programme implementation corresponds to decreased paediatric HZ incidence across age groups, in both vaccinated and unvaccinated individuals. Results from this study can be used to help inform varicella vaccination programme decision-making in other countries. Springer Berlin Heidelberg 2021-06-26 2021 /pmc/articles/PMC8520524/ /pubmed/34175998 http://dx.doi.org/10.1007/s10096-021-04298-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Rafferty, Ellen
Reifferscheid, Laura
Russell, Margaret L.
Booth, Stephanie
Svenson, Lawrence W.
MacDonald, Shannon E.
The impact of varicella vaccination on paediatric herpes zoster epidemiology: a Canadian population-based retrospective cohort study
title The impact of varicella vaccination on paediatric herpes zoster epidemiology: a Canadian population-based retrospective cohort study
title_full The impact of varicella vaccination on paediatric herpes zoster epidemiology: a Canadian population-based retrospective cohort study
title_fullStr The impact of varicella vaccination on paediatric herpes zoster epidemiology: a Canadian population-based retrospective cohort study
title_full_unstemmed The impact of varicella vaccination on paediatric herpes zoster epidemiology: a Canadian population-based retrospective cohort study
title_short The impact of varicella vaccination on paediatric herpes zoster epidemiology: a Canadian population-based retrospective cohort study
title_sort impact of varicella vaccination on paediatric herpes zoster epidemiology: a canadian population-based retrospective cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520524/
https://www.ncbi.nlm.nih.gov/pubmed/34175998
http://dx.doi.org/10.1007/s10096-021-04298-z
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