Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is an unremitting neurodegenerative disorder characterized by cerebral amyloid-β (Aβ) accumulation and gradual decline in cognitive function. Changes in brain energy metabolism arise in the preclinical phase of AD, suggesting an important metabolic component of early AD path...

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Detalles Bibliográficos
Autores principales: Andersen, Jens V., Skotte, Niels H., Christensen, Sofie K., Polli, Filip S., Shabani, Mohammad, Markussen, Kia H., Haukedal, Henriette, Westi, Emil W., Diaz-delCastillo, Marta, Sun, Ramon C., Kohlmeier, Kristi A., Schousboe, Arne, Gentry, Matthew S., Tanila, Heikki, Freude, Kristine K., Aldana, Blanca I., Mann, Matthias, Waagepetersen, Helle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520528/
https://www.ncbi.nlm.nih.gov/pubmed/34657143
http://dx.doi.org/10.1038/s41419-021-04237-y

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