Activation of angiotensin‐converting enzyme 2/angiotensin (1–7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling

Brain renin‐angiotensin (Ang) system (RAS) is implicated in neuroinflammation, a major characteristic of aging process. Angiotensin (Ang) II, produced by angiotensin‐converting enzyme (ACE), activates immune system via angiotensin type 1 receptor (AT1), whereas Ang(1–7), generated by ACE2, binds wit...

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Detalles Bibliográficos
Autores principales: Dang, Ruili, Yang, Mengqi, Cui, Changmeng, Wang, Changshui, Zhang, Wenyuan, Geng, Chunmei, Han, Wenxiu, Jiang, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520723/
https://www.ncbi.nlm.nih.gov/pubmed/34529881
http://dx.doi.org/10.1111/acel.13480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520723/
https://www.ncbi.nlm.nih.gov/pubmed/34529881
http://dx.doi.org/10.1111/acel.13480

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