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Antioxidant Vitamins and Carotenoids Intake and the Association With Poor Semen Quality: A Cross-Sectional Analysis of Men Referring to an Italian Fertility Clinic

Several studies suggested that male's diet affects fertility. This cross-sectional analysis from a prospective cohort study aims to explore the relation between antioxidants intake and sperm parameters in sub-fertile couples referring to a Fertility center. Socio-demographic characteristics, he...

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Autores principales: De Cosmi, Valentina, Parazzini, Fabio, Agostoni, Carlo, Noli, Stefania, Cipriani, Sonia, La Vecchia, Irene, Ferrari, Stefania, Esposito, Giovanna, Bravi, Francesca, Ricci, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520935/
https://www.ncbi.nlm.nih.gov/pubmed/34671631
http://dx.doi.org/10.3389/fnut.2021.737077
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author De Cosmi, Valentina
Parazzini, Fabio
Agostoni, Carlo
Noli, Stefania
Cipriani, Sonia
La Vecchia, Irene
Ferrari, Stefania
Esposito, Giovanna
Bravi, Francesca
Ricci, Elena
author_facet De Cosmi, Valentina
Parazzini, Fabio
Agostoni, Carlo
Noli, Stefania
Cipriani, Sonia
La Vecchia, Irene
Ferrari, Stefania
Esposito, Giovanna
Bravi, Francesca
Ricci, Elena
author_sort De Cosmi, Valentina
collection PubMed
description Several studies suggested that male's diet affects fertility. This cross-sectional analysis from a prospective cohort study aims to explore the relation between antioxidants intake and sperm parameters in sub-fertile couples referring to a Fertility center. Socio-demographic characteristics, health history, lifestyle habits, and diet information were obtained. A semen sample was analyzed to proceed with assisted reproduction. Three hundred and twenty-three men were enrolled: 19.1% had semen volume (SV) < 1.5 mL, 31.4% sperm concentration (SC) < 15.0 mil/mL, 26.8% sperm motility < 32%, and 33.0% had total sperm count (TSC) < 39.0 mil. Higher levels of α-carotene were associated to lower risk of low SC [4th vs. 1st quartile, adjusted OR (aOR) 0.43, 95% CI 0.20–0.91) and low TSC (aOR 0.46, 95% CI 0.22–0.95). Higher intake of β-carotene was inversely associated with risk of low TSC. Lycopene intake was associated with higher risk for these conditions (aOR 2.46, 95%CI 1.01–5.98, SC), and (aOR 3.11, 95%CI 1.29–7.50, TSC). Risk of low semen volume was lower in men with higher level of vitamin D intake (aOR 0.25, 95%CI 0.09–0.66)]. Further research, especially, well-designed randomized clinical trials (RCT), is needed to understand how diet modifications may have a role in modulating male fertility and fecundability.
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spelling pubmed-85209352021-10-19 Antioxidant Vitamins and Carotenoids Intake and the Association With Poor Semen Quality: A Cross-Sectional Analysis of Men Referring to an Italian Fertility Clinic De Cosmi, Valentina Parazzini, Fabio Agostoni, Carlo Noli, Stefania Cipriani, Sonia La Vecchia, Irene Ferrari, Stefania Esposito, Giovanna Bravi, Francesca Ricci, Elena Front Nutr Nutrition Several studies suggested that male's diet affects fertility. This cross-sectional analysis from a prospective cohort study aims to explore the relation between antioxidants intake and sperm parameters in sub-fertile couples referring to a Fertility center. Socio-demographic characteristics, health history, lifestyle habits, and diet information were obtained. A semen sample was analyzed to proceed with assisted reproduction. Three hundred and twenty-three men were enrolled: 19.1% had semen volume (SV) < 1.5 mL, 31.4% sperm concentration (SC) < 15.0 mil/mL, 26.8% sperm motility < 32%, and 33.0% had total sperm count (TSC) < 39.0 mil. Higher levels of α-carotene were associated to lower risk of low SC [4th vs. 1st quartile, adjusted OR (aOR) 0.43, 95% CI 0.20–0.91) and low TSC (aOR 0.46, 95% CI 0.22–0.95). Higher intake of β-carotene was inversely associated with risk of low TSC. Lycopene intake was associated with higher risk for these conditions (aOR 2.46, 95%CI 1.01–5.98, SC), and (aOR 3.11, 95%CI 1.29–7.50, TSC). Risk of low semen volume was lower in men with higher level of vitamin D intake (aOR 0.25, 95%CI 0.09–0.66)]. Further research, especially, well-designed randomized clinical trials (RCT), is needed to understand how diet modifications may have a role in modulating male fertility and fecundability. Frontiers Media S.A. 2021-10-04 /pmc/articles/PMC8520935/ /pubmed/34671631 http://dx.doi.org/10.3389/fnut.2021.737077 Text en Copyright © 2021 De Cosmi, Parazzini, Agostoni, Noli, Cipriani, La Vecchia, Ferrari, Esposito, Bravi and Ricci. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
De Cosmi, Valentina
Parazzini, Fabio
Agostoni, Carlo
Noli, Stefania
Cipriani, Sonia
La Vecchia, Irene
Ferrari, Stefania
Esposito, Giovanna
Bravi, Francesca
Ricci, Elena
Antioxidant Vitamins and Carotenoids Intake and the Association With Poor Semen Quality: A Cross-Sectional Analysis of Men Referring to an Italian Fertility Clinic
title Antioxidant Vitamins and Carotenoids Intake and the Association With Poor Semen Quality: A Cross-Sectional Analysis of Men Referring to an Italian Fertility Clinic
title_full Antioxidant Vitamins and Carotenoids Intake and the Association With Poor Semen Quality: A Cross-Sectional Analysis of Men Referring to an Italian Fertility Clinic
title_fullStr Antioxidant Vitamins and Carotenoids Intake and the Association With Poor Semen Quality: A Cross-Sectional Analysis of Men Referring to an Italian Fertility Clinic
title_full_unstemmed Antioxidant Vitamins and Carotenoids Intake and the Association With Poor Semen Quality: A Cross-Sectional Analysis of Men Referring to an Italian Fertility Clinic
title_short Antioxidant Vitamins and Carotenoids Intake and the Association With Poor Semen Quality: A Cross-Sectional Analysis of Men Referring to an Italian Fertility Clinic
title_sort antioxidant vitamins and carotenoids intake and the association with poor semen quality: a cross-sectional analysis of men referring to an italian fertility clinic
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520935/
https://www.ncbi.nlm.nih.gov/pubmed/34671631
http://dx.doi.org/10.3389/fnut.2021.737077
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